Results 291 to 300 of about 2,457,187 (381)

The TET3/GATA6 Axis Drives Lipid Metabolism and Therapeutic Vulnerabilities in Pancreatic Ductal Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
The DNA demethylase TET3 drives lipid metabolic reprogramming in pancreatic ductal adenocarcinoma via a non‐catalytic mechanism. TET3 recruits histone deacetylases to repress GATA6, sustaining lipogenic enzyme expression and ferroptosis resistance.
Shuai Liu   +8 more
wiley   +1 more source

Multifunctional Infrared Polarizer Based on Aligned Growth of High‐Density Boron Nitride Nanotubes

open access: yesAdvanced Science, EarlyView.
This paper presents a novel method for the high‐density, aligned growth synthesis and purification of boron nitride nanotubes (BNNTs). The polarization sensitivity and linear dichroism characteristics of BNNTs in the near‐infrared and mid‐infrared bands are comprehensively verified.
Ningqiang Shi   +9 more
wiley   +1 more source

MoS2 Channel‐Enhanced High‐Density Charge Trap Flash Memory and Machine Learning‐Assisted Sensing Methodologies for Memory‐Centric Computing Systems

open access: yesAdvanced Science, EarlyView.
Driven by AI computing demands, this study investigates MoS2 channels for 3D NAND Flash to achieve high‐density, low‐power, and reliable nonvolatile memory. MoS2 enables a large memory window and lower operating voltages with low‐k tunneling layer, demonstrating endurance of 10⁴ cycles and retention of 10⁵ s. Comprehensive analyses and machine learning‐
Ki Han Kim   +7 more
wiley   +1 more source

RSPO2 Coordinates with GDF9:BMP15 Heterodimers to Promote Granulosa Cell and Oocyte Development in Mice

open access: yesAdvanced Science, EarlyView.
RSPO2 and GDF9:BMP15 heterodimers—core components of oocyte‐secreted factors (OSFs)—coordinate to shape the molecular architecture of preantral granulosa cells via gene‐specific synergistic and antagonistic regulation, mediated through CTNNB1–SMAD2 signaling crosstalk.
Yingmei Wang   +7 more
wiley   +1 more source

Long Term High‐Salt Diet Induces Cognitive Impairments via Down‐Regulating SHANK1

open access: yesAdvanced Science, EarlyView.
The study identifies a novel mechanistic link between long‐term HS diet and cognitive impairment, wherein PKA/CREB axis inactivation leads to SHANK1 reduction, synaptic damage, and cognitive deficits. Abstract High‐salt (HS) diet is an established risk factor for cognitive impairment, but the underlying mechanisms remain unclear.
Cuiping Guo   +10 more
wiley   +1 more source

Cryo‐Exfoliation Synthesis of Borophene and its Application in Wearable Electronics

open access: yesAdvanced Science, EarlyView.
This article introduces a novel cryo‐exfoliation method for synthesizing borophene, utilizing rapid quenching with liquid nitrogen and mild sonication to achieve scalable, high‐purity nanosheets. The study explores advanced characterizations, molecular dynamics simulations, and borophene‐based nanocomposites for wearable electronics, demonstrating its ...
Zhixuan Li   +6 more
wiley   +1 more source

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