Drimanes from Drimys brasiliensis with leishmanicidal and antimalarial activity [PDF]
Memorias do Instituto Oswaldo Cruz, 2013 This paper evaluates CHCl3 and CH3OH extracts of the stem bark, branches and leaves of Drimys brasiliensis and drimane sesquiterpenes isolated from the stem bark against strains of Leishmania amazonensis and Leishmania braziliensis promastigotes and ...
Vanessa Duarte Claudino +8 more
doaj +5 more sources
Spirocyclic Drimanes from the Marine Fungus Stachybotrys sp. Strain MF347 [PDF]
Marine Drugs, 2014 A novel spirocyclic drimane coupled by two drimane fragment building blocks 2 and a new drimane 1 were identified in mycelia and culture broth of Stachybotrys sp. MF347. Their structures were established by spectroscopic means.
Bin Wu +5 more
doaj +4 more sources
Biosynthesis of Fungal Drimane-Type Sesquiterpene Esters. [PDF]
Angew Chem Int Ed Engl, 2021 Reported here is the complete elucidation of the biosynthetic pathway of drimane‐type sesquiterpene esters from Aspergillus calidoustus, including the first identified fungal drimenol cyclase. The cluster‐associated acyltransferase is then employed to transfer different lengths of ACP‐activated polyketides, but also very diverse CoA‐esters.
Huang Y, Hoefgen S, Valiante V.
europepmc +7 more sources
Anticancer Activity of Natural and Semi-Synthetic Drimane and Coloratane Sesquiterpenoids [PDF]
Molecules, 2022 Drimane and coloratane sesquiterpenoids are present in several plants, microorganisms, and marine life. Because of their cytotoxic activity, these sesquiterpenoids have received increasing attention as a source for new anticancer drugs and pharmacophores.
Lorenz Beckmann +3 more
doaj +2 more sources
Research Advances of Bioactive Sesquiterpenoids Isolated from Marine-Derived Aspergillus sp. [PDF]
Molecules, 2022 Marine fungi Aspergillus sp. is an important source of natural active lead compounds with biological and chemical diversity, of which sesquiterpenoids are an extremely important class of bioactive secondary metabolites.
Lixiang Sun +4 more
doaj +2 more sources
Chemical Diversity and Biosynthesis of Drimane-Type Sesquiterpenes in the Fungal Kingdom. [PDF]
Chembiochem, 2022 Fungal drimane‐type sesquiterpenes (DTSs) are emerging as a very interesting class of chemicals with many notable activities. Elucidation of DTS biosynthesis in fungi revealed that the two main precursors, drimenol and drim‐8‐ene‐11‐ol, are the preferred backbones.
Huang Y, Valiante V.
europepmc +2 more sources
Isolation, (bio)synthetic studies and evaluation of antimicrobial properties of drimenol-type sesquiterpenes of Termitomyces fungi [PDF]
Communications Chemistry, 2023 Macrotermitinae termites have farmed fungi in the genus Termitomyces as a food source for millions of years. However, the biochemical mechanisms orchestrating this mutualistic relationship are largely unknown.
Nina B. Kreuzenbeck +13 more
doaj +2 more sources
Genetic mechanism of bicyclic sesquiterpanes in Upper Triassic source rock of Yinan 2 well from the Kuqa Depression of Tarim Basin, China [PDF]
Scientific ReportsBicyclic sesquiterpanes are widely distributed in terrigenous sedimentary organic matter and are serve as valuable biomarker in the field of organic geochemistry.
Yiman Zhang +6 more
doaj +2 more sources
Structural Requirements for the Antifungal Activities of Natural Drimane Sesquiterpenes and Analogues, Supported by Conformational and Electronic Studies [PDF]
Molecules, 2013 Seventeen drimanes including polygodial (1), isopolygodial (2), drimenol (3) and confertifolin (4) obtained from natural sources and the semi-synthetic derivatives 5–17 obtained from 1–3, were evaluated in vitro for antifungal properties against a unique
Susana A. Zacchino +5 more
doaj +2 more sources
Natural Products from Marine Fungi—Still an Underrepresented Resource [PDF]
Mar Drugs, 2016 Marine fungi represent a huge potential for new natural products and an increased number of new metabolites have become known over the past years, while much of the hidden potential still needs to be uncovered.
Imhoff, Johannes F.
core +3 more sources