Results 171 to 180 of about 809,394 (251)

Joint effects of real-world cue exposure and affective states on momentary alcohol craving in adults with alcohol use disorder. [PDF]

Drug Alcohol Depend Rep
Aggarwal A, Monti PM, Promrat K, Magill M, Mellinger JL, Padovano HT.   +5 more
europepmc   +1 more source

Adhesion‐Enhanced Engineered Probiotic for Prolonged Intestinal Retention and Calprotectin‐Responsive IBD Therapy

Advanced Science, EarlyView.
An intelligent engineered probiotic platform is developed for the precision management of inflammatory bowel disease. By integrating surface‐displayed adhesins with an inflammation‐responsive CAT‐SOD‐GPx tripartite fusion system and mucosal repair factors, this programmable system achieves prolonged intestinal retention and multi‐pronged therapy.
Yuxi Wang, Peichao Zhang, Simin Gu, Hongyun Lu, Ningning Jiang, Jiarun Zhao, Enbo Xu, Xiayu Liu, Ying Shi, Qihe Chen   +9 more
wiley   +1 more source

Daily Drinking Behaviors and the Influence of Rumination, Impulsivity, and Social Drinking Contexts. [PDF]

Subst Use Misuse
Morgan DD, Fleming M, Dugan K, Hough T, Yan S, Trull TJ.   +5 more
europepmc   +1 more source

Isocyanate‐Modified Melatplatin(IV) Enhances Antitumor Efficacy via TCF4/COL6A3‐Mediated Extracellular Matrix Remodeling and cGAS‐STING Pathway Activation in Bladder Cancer

Advanced Science, EarlyView.
A series of melatonin‐conjugated platinum(IV) prodrugs was functionalized with isocyanate chains (compounds 5‒12). MP‐12C (compound 11) was identified as the lead candidate, with optimal potency and safety. MP‐12C exhibited greater efficacy than cisplatin by increasing intracellular uptake, reshaping the extracellular matrix, activating the cGAS‐STING ...
Linhui Wang, Xiaomeng Liu, Tao Zhu, Zirun Su, Ruiping Liu, Zhe Li, Kaixuan Du, Kaipeng Jia, Chong Fu, Yuda Lin, Zihan Xue, Zhe Zhang, Chong Shen, Yunkai Qie, Zhouliang Wu, Zhiheng Liu, Kangkang Liu, Jingyuan Xu, Hailong Hu   +18 more
wiley   +1 more source

Sexual Victimization Experiences and Binge Drinking Frequency Among Bisexual+ and Heterosexual Women. [PDF]

J Child Sex Abus
Masterson AP, Scaglione NM, Wang W, Westmoreland DA, Berry MS, Hone LSE.   +5 more
europepmc   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Developmental Environmental Chronotoxicity by Polystyrene Nanoplastics Exacerbates High‐Fat Diet‐Induced Pediatric MAFLD Through Circadian Disruption and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Polystyrene nanoplastics exacerbate high‐fat diet‐induced metabolic dysfunction in an age‐dependent manner. Juvenile mice exhibit greater susceptibility, characterized by circadian disruption, impaired mitochondrial function, reduced energy metabolism, and enhanced hepatic lipid accumulation.
Peihao Xu, Shuting Huang, Leilei Zhu, Junyi Huang, Kewei Li, Guangming Li, Jiannong Wu, Mingyuan Zhou, Fangmei Zhou, Zhishan Ding, Yingzhi Shen   +10 more
wiley   +1 more source

Laboratory and pilot-farm evaluation of cleaning and disinfection protocols for biofilms in livestock drinking water systems. [PDF]

Biofilm
Van Rossum U, Heyndrickx M, Demaître N, Rasschaert G, Boon N, Cools A, De Reu K.   +6 more
europepmc   +1 more source

Self‐Healing UPy‐Functionalized Polyethylene Networks: A Robust Platform for Resilient and High‐Performance Lithium Battery Separators

Advanced Science, EarlyView.
Self‐healing separators are developed by grafting ureidopyrimidinone (UPy) quadruple hydrogen‐bonding motifs onto PE‐HEMA copolymers, blended with high‐MW PEO via solvent‐free hot‐pressing. The dynamic UPy network enables autonomous healing, restoring functionality after short circuits.
Daniele Callegari, Arkadiusz Zych, Roberta Pinalli, Enrico Dalcanale, Eliana Quartarone   +4 more
wiley   +1 more source

Psychosocial Interventions for Alcohol Use Disorder: A Review of Efficacy, Mechanisms, and Clinical Implications. [PDF]

Med Sci Monit
Peng J, Wei L, Liang Y, Tan Y.
europepmc   +1 more source