Results 281 to 290 of about 6,448,369 (384)

Ethanol Induces Long-Term Facilitation of NR2B-NMDA Receptor Activity in the Dorsal Striatum: Implications for Alcohol Drinking Behavior [PDF]

open access: hybrid, 2007
Jun Wang   +8 more
openalex   +1 more source

Drinking behavior and sources of alcohol: differences between Native American and White youths.

open access: yesJournal of Studies on Alcohol and Drugs, 2011
Bettina Friese   +4 more
semanticscholar   +1 more source

Akkermansia muciniphila‐Derived N‐Acetylspermidine Modulates the Localization of Intestinal α1,2‐Fucosylated Proteins to Maintain Gut Homeostasis

open access: yesAdvanced Science, EarlyView.
This study demonstrates that Akkermansia muciniphila alleviates colitis by enhancing intestinal α1,2‐fucosylation through its metabolite N‐acetylspermidine. Mechanistically, N‐acetylspermidine‐induced PIM1 inhibition promotes HDAC2‐mediated reduction of chromatin accessibility at TP73, thereby upregulating C1GALT1C1 to boost α1,2‐fucosylation.
Ye Yao   +10 more
wiley   +1 more source

Macrophage Zc3h12c Limits Tissue Inflammation and Injury via Alternative Splicing of Pre‐mRNA

open access: yesAdvanced Science, EarlyView.
This work defines the context‐dependent function of Zc3h12c in macrophages using the Tnfrsf11a‐Cre system. It reveals Zc3h12c's dual mechanism—regulating RNA degradation and alternative splicing—with STAT1 as a key target. The findings elucidate a novel post‐transcriptional pathway and identify STAT1 isoforms as potential therapeutic targets for kidney
Chenyu Li   +14 more
wiley   +1 more source

KLK1 as an Epithelial‐Specific Brake Inhibits Colorectal Tumorigenesis by Suppressing B1R‐Mediated Fibroblast Phenotypic Transition

open access: yesAdvanced Science, EarlyView.
KLK1 downregulation disrupts the intestinal mucosal barrier and impairs kallikrein‐kinin signaling, thereby reducing Lys‐des‐Arg9‐BK production. This enhances B1R activation on ADAMDEC1⁺ fibroblasts, promoting inflammation and extracellular matrix (ECM) remodeling. The resulting iCAFs promote colorectal cancer progression, highlighting a novel KLK1‐B1R
Lisha Zhou   +14 more
wiley   +1 more source

Comparison of behaviors on drinking by age group among females of 20-75 years of age

open access: bronze, 2004
Fumiko Hayakawa   +7 more
openalex   +2 more sources

Evaluating a cognitive model of ALDH2 and drinking behavior.

open access: yesAlcoholism: Clinical and Experimental Research, 2011
C. Hendershot   +6 more
semanticscholar   +1 more source

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