Results 181 to 190 of about 5,874,199 (333)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Changes in geographic drive time access to pre-exposure prophylaxis (PrEP) in the United States, 2017 to 2025. [PDF]

Prev Med Rep
Mancuso N, Weiss K, Siegler AJ, Sullivan PS.   +3 more
europepmc   +1 more source

Days on Dixie Drive [PDF]

, 2018
LaRosa, Mariesa
core   +1 more source

Do Managerial Objectives Drive Bad Acquisitions?

, 1989
R. Morck, Andrei Shleifer, Robert W. Vishny   +2 more
semanticscholar   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

« Mutations de l’espace marchand », DESSE R-P., LESTRADE S. (Dir.)

Netcom, 2016
Emilie Demoyer
doaj   +1 more source

Fast superconducting qubit control with subharmonic drives. [PDF]

Nat Commun
Xia M, Zhou C, Liu C, Patel P, Cao X, Lu P, Mesits B, Mucci M, Gorski D, Pekker D, Hatridge M.   +10 more
europepmc   +1 more source

Cliff driving [PDF]

Science, 2017
openaire   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Strategies to improve the efficiency of homing gene drives with multiplexed gRNAs. [PDF]

BMC Biol
Chen W, Wu P, Champer J.
europepmc   +1 more source