Results 61 to 70 of about 309,624 (329)
Cas9-triggered chain ablation of cas9 as a gene drive brake
Nature Biotechnology, 2016 With the advent of clustered, regularly interspaced, short palindromic repeats (CRISPR)–CRISPR-associated protein 9 (Cas9) technology, researchers can construct gene drives that can bias the inheritance of edited alleles to alter entire populations.
Bing Wu, L. Luo, Xiaojing J. Gao
semanticscholar +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Contact Analysis of Chain Drive in Scraper Conveyor Based on Dynamic Meshing Properties
, 2018 The chain drive system is the most important subsystem in a mining scraper conveyor. Compared with the general chain drive system, that in a scraper conveyor is highly coupled.
S. B. Jiang +5 more
semanticscholar +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Supply Chain Information Systems and Organisational Performance in Economic Turbulent Times
, 2015 Supply Chain Information Systems and their impact on organisational performance has been studied by a number of studies. This study seeks to extend this body of knowledge by adopting a fresh lens to explore empirically the relationship between ...
Reid, Iain +3 more
core
INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT, 2022 -India is the second largest producer and manufacturer of two-wheelers in the world. It stands next to Japan and China in terms of the number of two- wheelers produced and domestic sales. The face of auto industry that was redefined with the invention of fuel- efficient technology is all set to see dawn of a new era in two-wheeler industry. It's not
openaire +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Determination of impact stresses in an automotive chain drive component
, 2006 A photoelastic stress analysis technique has been used to determine the contact stresses in an automotive chain drive tensioner. The tensioner in normal operation is subject to high magnitude, short duration impact stresses.
A. Ward +7 more
core +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
, 2017 This paper presents a study on optimum determination of partial ratios of mechanical drive systems using a chain drive and two-step helical gearbox for getting minimum size of the system.
Vu Ngoc Pi +2 more
semanticscholar +1 more source