Results 61 to 70 of about 952,700 (265)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Design and Test of the Electrical System of the All-Electric Subsea Gate Valve Actuator

Actuators
To bridge the gap in the research on the control and drive methods of the key equipment of the new subsea production control system, all-electric subsea gate valve actuator, and to solve the problems of the valve control and drive system in the ...
Honghai Wang, Guiqian Liu, Lai Zhou, Peng Jia, Feihong Yun   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Optimization Design of Drive Mode of Coiled Tubing Injector Head

Shiyou jixie, 2017
At present, there are some defects in the actual use of coiled tubing injector head drive method. In order to address these defects and improve the performance of the injector head, focusing on the structural characteristics of the injector head and ...
Duan Wenyi, Liu Pingguo, Liu Fei, Ma Qing, Hao Jun, Hu Zhiqiang   +5 more
doaj  

Modification of the method of hierarchy analysis based on the elimination of the subjectivity of expert assessments using the example of choosing a rational option for a belt conveyor drive system [PDF]

Научно-технический вестник Брянского государственного университета
The expert assessment method underlies most decision-making methods in the technical field of activity, from the search for rational design solutions to issues of industrial safety of hazardous production facilities, which is embodied in the form of ...
Goncharov K.A.
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Determination of relative immobile and sliding areas between carrying and tractive belts in using of belt conveyor intermediate drives [PDF]

Научно-технический вестник Брянского государственного университета, 2015
Method of determination of relative immobile and sliding areas between carrying and tractive belts in places of mount-ing of belt conveyor intermediate drives made in the form of tractive contours is proposed.
Goncharov K.A.
doaj