Results 231 to 240 of about 4,023,817 (302)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Medical AI across Data Regimes to Promote Proactive Health. [PDF]

Health Data Sci
Li P, Wu J, Zuo Q, Zhang L, Zhan Q.
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Theory and evidence of amplitude control by frequency detuning in a coupled neuronal oscillator system. [PDF]

PLoS Comput Biol
Lu AC, Ourang SA, Moore JD.
europepmc   +1 more source

Correction: Microbial reassembly-driven multi-niche functional compensation alleviates uranium stress in rapeseed. [PDF]

Front Microbiol
Frontiers Production Office.
europepmc   +1 more source

Twist degree of freedom activated by pressure-driven interlayer engineering in spiral WS₂. [PDF]

Nat Commun
Ci P, Sun M, Chen Y, Rho Y, Zhao Y, Xin K, Mai Z, Liang S, Wang Z, Wu J, Hong H, Wei Z, Grigoropoulos CP, Liu YY, Tan PH, Wu J.   +15 more
europepmc   +1 more source

Drivers of exploration early in development: Perceptual novelty rather than a quest for information. [PDF]

Dev Psychol
Gao M, Sloutsky V.
europepmc   +1 more source