Results 91 to 100 of about 41,403 (263)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Enhancing Autonomous Vehicle Decision-Making at Intersections in Mixed-Autonomy Traffic: A Comparative Study Using an Explainable Classifier

Sensors
The transition to fully autonomous roadways will include a long period of mixed-autonomy traffic. Mixed-autonomy roadways pose a challenge for autonomous vehicles (AVs) which use conservative driving behaviours to safely negotiate complex scenarios. This
Erika Ziraldo, Megan Emily Govers, Michele Oliver   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

An Analysis of Driver Behaviour Through Rural Curves: Exploratory Results on Driver Speed

Journal of Road Safety, 2015
Speed, whether above the speed limit or too fast for the conditions, is a significant contributor to fatal and serious injuries at curves on rural roads. The driving behaviour of 40 motorists was assessed using an instrumented vehicle.
Blair Turner, Jeremy Woolley, Peter Cairney   +2 more
doaj  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Modelling driver behaviour in soar

, 1995
Deze studie beschrijft een cognitief model van het gedrag van een automobilist bij het naderen en afhandelen van kruisingen. Het model bestuurt een gesimuleerde auto in een gesimuleerde verkeerswereld waarin ook andere auto's en fietsers rondrijden. De belangrijkste rijtaken die het model uitvoert zijn het afhandelen van ongeordende kruisingen, het ...
openaire   +2 more sources

Early‐Phase Research in Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
Jonathan Cunningham
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

DRIVER INATTENTION Drivers' Perception of Risks and Compensating Behaviours

IATSS Research, 2004
Driver inattention, especially driver distraction, is an extremely influential but generally neglected contributing factor of road crashes. This paper explores some of the common behaviours associated with several common forms of driver inattention, with respect to their perceived crash risks, rates of self-reported behaviours and whether drivers ...
Tay, Richard, Knowles, David
openaire   +1 more source