Results 161 to 170 of about 1,821 (211)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

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Zero-to-Stable Driver Identification: A Non-Intrusive and Scalable Driver Identification Scheme

IEEE Transactions on Vehicular Technology, 2020
Driver identification faces various challenges in real-time applications. These challenges include high dimensional input data, moderate accuracy, scalability issues and need for custom-built in-vehicle sensors. The conventional biometric solutions are either less accurate, unscalable, or costly for practical application.
Keke Gai, Jiamou Liu, Zijian Zhang
exaly   +2 more sources

Driver Modeling Based on Driving Behavior and Its Evaluation in Driver Identification

Proceedings of the IEEE, 2007
All drivers have habits behind the wheel. Different drivers vary in how they hit the gas and brake pedals, how they turn the steering wheel, and how much following distance they keep to follow a vehicle safely and comfortably. In this paper, we model such driving behaviors as car-following and pedal operation patterns.
Kazuya Takeda, Fumitada Itakura
exaly   +2 more sources

Driver Identification Through Formal Methods

IEEE Transactions on Intelligent Transportation Systems, 2022
Recently, several research efforts have been focused on automotive safety, due to the increasing technology embedded in our vehicles. Research community have produced different methods aimed, for instance, to profile driver behaviour, starting from a feature set gathered by the vehicle.
Martinelli F., Mercaldo F., Nardone V., Santone A.   +3 more
openaire   +4 more sources

An Explainable Approach for Car Driver Identification

2021 IEEE International Conference on Fuzzy Systems (FUZZ-IEEE), 2021
The increasing number of always more sophisticated car sensors, which allow to extract information about the driver, encourages auto vehicle developers and researchers to focus on the topic of driver identification. The advantages can be various, such as to customise and improve driver experience, to increase safety and to reduce global environmental ...
Gallo G., Bernardi M. L., Cimitile M., Ducange P.   +3 more
openaire   +2 more sources

Identification of the Driver in an Automobile Collision

The American Journal of Forensic Medicine and Pathology, 1990
We report on a three-occupant automobile collision in which one of the two survivors claimed that the deceased had operated the vehicle. We attempted to identify the driver. The left face and neck of the deceased appeared to have struck the vehicle's interior. The survivors were slightly injured on the right side of their faces. In Japan, the passenger
A, Akane, H, Shiono, K, Matsubara, S, Takahashi   +3 more
openaire   +2 more sources

Biometric Driver Identification

SAE Technical Paper Series, 2008
<div class="htmlview paragraph">This paper deals with the use of biometric methods of driver identification in the vehicle. It compares different methods and evaluates their possible uses in the vehicle. The methods of fingerprint, iris recognition and face recognition are dealt with in particular.</div> <div class="htmlview paragraph ...
Ulrich Bueker, Ruediger Schmidt, Tristan Eickhoff   +2 more
openaire   +1 more source

Race driver model: identification of the driver’s inputs

2008
Once the best trajectory has been determined (both in terms of best track and best speed profile), it is necessary to identify the driver’s inputs to follow the given trajectory. The driver’s inputs are the following: the gear, the clutch, the brake, the accelerator and the steer wheel.
BRAGHIN, FRANCESCO, CHELI, FEDERICO, SABBIONI, EDOARDO   +2 more
openaire   +2 more sources