Results 81 to 90 of about 89,984 (298)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Study on Intelligent Early Warning System of Railway Locomotive Driver Operation State

机车电传动, 2018
In order to solve the online real-time monitoring problems on railway locomotive driver operation state, face image tracking and human pupil biological image recognition technology was applied, and vehicle intelligent detection device, data transmission ...
QU Surong, ZHANG Zhongyang, ZHANG Xianfeng   +2 more
doaj  

Test procedure for the evaluation of partially automated driving HMI including driver monitoring systems in driving simulation

MethodsX
The proposed test procedure presents an approach for the evaluation of the usability of partial automated driving HMI including driver monitoring systems in driving simulation.
Nadja Schömig, Christina Kremer, Sebastian Gary, Yannick Forster, Frederik Naujoks, Andreas Keinath, Alexandra Neukum   +6 more
doaj   +1 more source

"IoT-Based Vehicle Monitoring and Driver Assistance System Framework for Safety and Smart Fleet Management"

, 2023
Bhuvendhraa Rudrusamy, Hock Chye Teoh, Jia Yew Pang, Tou Hong Lee, TMS-Lite Sdn Bhd, Sung Choong Chai, CPeEnergy Sdn Bhd   +6 more
openalex   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Hybrid deep learning framework for enhancing real-time driver safety systems [PDF]

AIP Advances
Advanced monitoring technologies that can instantly assess the surrounding environment and driver behavior are required to solve this problem. In this study, we present a hybrid deep learning framework for improving real-time driver safety by leveraging ...
Pavunkumar Devaraj, Santhosh Babu A. V., Johny Renoald Albert   +2 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Optimization of Event Camera Bias Settings for a Neuromorphic Driver Monitoring System

IEEE Access
Event cameras provide a novel imaging technology for high-speed analysis of localized facial motions such as eye gaze, eye-blink and micro-expressions by taking input at the level of an individual pixel.
Mehdi Sefidgar Dilmaghani, Waseem Shariff, Muhammad Ali Farooq, Joe Lemley, Peter Corcoran   +4 more
doaj   +1 more source

Development of a Real-Time Driver Health Detection System Using a Smart Steering Wheel

International Journal of Prognostics and Health Management, 2018
The number of vehicle accidents due to driver drowsiness continues to increase. Therefore, prompt and effective detection for driver health during driving is crucial to improvement of traffic safety.
Jae-Cheon Lee, Hao Liu
doaj   +1 more source