Results 161 to 170 of about 182,013 (307)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

open access: yesFEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana   +5 more
wiley   +1 more source

Driving forces for the subcellular localization of peripheral proteins.

open access: yes, 2003
Driving forces for the subcellular localization of peripheral ...
Robert Virgil. Stahelin (7969454)
core  

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

open access: yesFEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow   +12 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

open access: yesAging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Study of Driving Forces for Atomic Migration in Dilute Alloys

open access: yes, 2011
We present a pseudopotential calculation of the driving forces for atomic migration in the 156 dilute alloys of the 23 host of the different groups of the periodic table in the presence
M. Vora, Aditya
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

open access: yesAging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang   +3 more
wiley   +1 more source

Commentaires sur les forces motrices des changements dans l'agriculture paysanne rwandaise 1990-2001: Agriculture et Elevage

open access: yes
The purpose of this policy synthesis is to document major shifts in output and provide hypotheses about the reasons behind the changes. The paper also documents troubling trends in the traditional agriculture sector, underscoring the need for improved ...
Loveridge, Scott   +2 more
core   +1 more source

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