Results 131 to 140 of about 484,206 (263)

Lithospheric delamination as the driving mechanism of intermediate-depth seismicity in the Bucaramanga Nest, Colombia. [PDF]

Sci Rep, 2023
Pérez-Forero D, Koulakov I, Vargas CA, Gerya T, Al Arifi N.   +4 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Trained Immunity-Like Memory in Vascular Structural Cells: Metabolic-Epigenetic Reprogramming as a Driving Mechanism of Atherosclerosis and Residual Cardiovascular Risk. [PDF]

J Inflamm Res
Dai J, Zhou X, Yuan K, Huang K, Zhang Y.
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Correction: Research on the supply-demand balance evaluation and driving mechanism of community public service facilities. [PDF]

PLoS One
Chen J, Fu Y, Ma S, Chen Q, Zhang W, Huang J.   +5 more
europepmc   +1 more source

Spatial distribution pattern and driving mechanism of tourist attractions in Gansu Province based on POI data. [PDF]

PLoS One, 2023
Peng R, Gao W.
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The driving mechanism of innovative behavior of vocational education students: an analysis of the role of psychological satisfaction, intrinsic motivation and career needs. [PDF]

Front Psychol
Xiaoping X, Chenhui W, Jiawei T, Dian J, Fanghe X.   +4 more
europepmc   +1 more source

Study on the Spatial-Temporal Pattern and Driving Mechanism of Tourism Eco-Security in the Yellow River Basin. [PDF]

Int J Environ Res Public Health, 2023
Zhao J, Wang S, Li J.
europepmc   +1 more source

Understanding the molecular mechanisms driving metastasis [PDF]

Molecular Oncology, 2017
Massagué, Joan, Batlle, Eduard, Gomis, Roger R.   +2 more
openaire   +2 more sources