Results 171 to 180 of about 4,356,687 (302)

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

The driving mechanism of innovative behavior of vocational education students: an analysis of the role of psychological satisfaction, intrinsic motivation and career needs. [PDF]

Front Psychol
Xiaoping X, Chenhui W, Jiawei T, Dian J, Fanghe X.   +4 more
europepmc   +1 more source

Spatial distribution pattern and driving mechanism of tourist attractions in Gansu Province based on POI data. [PDF]

PLoS One, 2023
Peng R, Gao W.
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Vacancy-Mediated Bound Magnetic Polarons as the Driving Mechanism for Ferromagnetism in Fe-Doped SnO₂ Nanowires. [PDF]

ACS Omega
Montalvo D, Hoat DM, Gómez-Vidales V, de la Cruz Hernández WJ, Camacho-López S, Carrera K, Orozco V, Guerrero-Sánchez J, Herrera M.   +8 more
europepmc   +1 more source

Study on the Spatial-Temporal Pattern and Driving Mechanism of Tourism Eco-Security in the Yellow River Basin. [PDF]

Int J Environ Res Public Health, 2023
Zhao J, Wang S, Li J.
europepmc   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

The coupling and coordination degree and driving mechanism of water and land resources in the Beijing-Tianjin-Hebei urban agglomeration. [PDF]

PLoS One
Chen W, Lian M.
europepmc   +1 more source

Characteristics and Driving Mechanism of Water Resources Trend Change in Hanjiang River Basin. [PDF]

Int J Environ Res Public Health, 2023
Kong M, Zhao J, Zang C, Li Y, Deng J.
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source