Results 61 to 70 of about 778,530 (187)

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

Teen safe driving in Connecticut

, 2011
Annual; "Annual Report on Effectiveness of Connecticut's Teen Driving Laws."; Harvested from the web on 8/18 ...

core  

Recent progress on the development of hydrogel‐based microneedles for transdermal drug delivery

VIEW, EarlyView.
This study provides a comprehensive and up‐to‐date analysis of recent progress in HMN technology, covering fundamental transdermal delivery mechanisms and design principles, biomaterials used in HMN fabrication, drug loading and release strategies, and emerging therapeutic applications.
Mohammad Muhtasim Ittisaf, Salman Farsi Taharat, Md. Sadek Miah, Hasan Tasnim Salehin, M. Azam Ali, Shoeb Ahmed   +5 more
wiley   +1 more source

Economic Burden and Treatment Patterns Among Patients Diagnosed With Vitiligo in Japan: An Observational Retrospective Cohort Study

The Journal of Dermatology, EarlyView.
ABSTRACT Vitiligo, a common and chronic depigmentation disorder, significantly impacts patients' quality of life and exerts a substantial economic burden. The deleterious impact of vitiligo can be exacerbated by comorbid conditions, including psychiatric and autoimmune conditions.
Naoki Oiso, Kent A. Hanson, Ahmed M. Soliman, Chao Li, Manabu Taura, Daniel Mercer, Andrew Rava, Danielle Bynoe, Haiyan Sun, Tamio Suzuki   +9 more
wiley   +1 more source

Nocturnal Behavior of Wintering Common Cranes (Grus grus) Under Varying Environmental Conditions

Integrative Zoology, EarlyView.
For diurnal species, nighttime represents a critical ecological boundary. Understanding the ecological determinants of nocturnal activity in taxa traditionally regarded as inactive after dusk is essential for elucidating the adaptive significance of nighttime behavior. We examined how night phase, nocturnal brightness (moon illumination and cloud cover)
Flavio Monti, Marco Ciolfi, Giuseppe Anselmi, Niccolò Fattorini, Francesco Ferretti   +4 more
wiley   +1 more source

Multidimensional Determinants of Quality of Life in Men With Klinefelter Syndrome: A Narrative Review of Workshop Evidence

Andrology, EarlyView.
ABSTRACT Background Klinefelter syndrome (KS), typically characterized by a 47, XXY karyotype, is the most common sex chromosomal aneuploidy in males, with a prevalence of approximately one in 600–660 individuals. Despite its frequency, the syndrome remains significantly underdiagnosed, with 50%–75% of affected individuals never receiving a clinical ...
Francesca Allosso, Lucia Digitale Selvaggio, Daniela Pasquali   +2 more
wiley   +1 more source

Why are people afraid of the dentist?:Observations and explanations [PDF]

, 2014
Objective: The aim of this review was to explore the peer-reviewed literature to answer the question: 'Why are people afraid of the dentist?' Method: Relevant literature was identified by searching the following on-line databases: PubMed, PsycInfo, the ...
Beaton, Laura, Beaton, L.; id_orcid, Freeman, R.; id_orcid, Humphris, G., Humphris, Gerald Michael, Freeman, Ruth   +5 more
core   +1 more source

A qualitative investigation of the lived experiences of adults with anxiety and related disorders and ADHD: Interconnectedness of symptoms and implications for improving care

British Journal of Clinical Psychology, EarlyView.
Abstract Background Attention‐deficit/hyperactivity disorder (ADHD) is highly prevalent in adults with anxiety and related disorders (ARDs). Quantitative research on this clinical population is mixed, with some studies suggesting that anxiety is protective against some symptoms of ADHD and others in which co‐occurring ARDs and ADHD are linked to poorer
Arij Alarachi, Heather McNeely, Karen Rowa, Randi E. McCabe   +3 more
wiley   +1 more source

Imagery rescripting for generalized anxiety disorder: A case series

British Journal of Clinical Psychology, EarlyView.
Abstract Introduction This is the first clinical pilot to explore the feasibility, acceptability and preliminary efficacy of imagery rescripting in individuals with a diagnosis of generalized anxiety disorder (GAD). Methods Participants with GAD (N = 18) attended assessment and 10 weekly sessions of imagery rescripting with a psychologist in person or ...
L. Stavropoulos, A. B. Phipps, I. Sabel, D. D. J. Cooper, N. Briggs, J. M. Newby, J. R. Grisham   +6 more
wiley   +1 more source

Positive modulation of glucagon‐like peptide 1 (GLP‐1) receptor by endogenous haemorphins with implications in glucose metabolism and diabetes

British Journal of Pharmacology, EarlyView.
Haemorphins act on GLP‐1 receptor (GLP‐1R) activity and signalling in a positive allosteric manner. This leads to potentiated GLP‐1‐mediated activity and signalling, as well as insulin synthesis, which may have implications for glucose metabolism and, thereby, diabetes and obesity. (The graph was created in BioRender.com).
Farheen Badrealam Khan, Rwdah Mohamed Alameri, Yasir S. Raouf, Damien Maurel, Naiem Ahmad Wani, Anatoliy Shmygol, Irfa Anwar, Heng B. See, Elizabeth K. M. Johnstone, Elodie Dupuis, Eric Trinquet, Kevin D. G. Pfleger, Emilia Oueis, Mohammed Akli Ayoub   +13 more
wiley   +1 more source