Results 71 to 80 of about 557,353 (285)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
The Reliability of Countermovement Jump Performance and the Reactive Strength Index in Identifying Drop-Jump Drop Height in Hurling Players [PDF]
, 2017 The purpose of this study was to estimate the inter-day reliability of countermovement jump performance (CMJ) and the reactive strength index (RSI) in identifying drop-jump drop height in male hurling players.
Cooper, Stephen-Mark +3 more
core
Changes in long jump take-off technique with increasing run-up speed [PDF]
, 2006 The aim of this study was to determine the influence of run-up speed on take-off technique in the long jump. Seventy-one jumps by an elite male long jumper were recorded in the sagittal plane by a high-speed video camera.
Bridgett, LA, Linthorne, NP
core +1 more source
Numerical and Experimental Simulation of the B-jump in an Abrupt Roughened Bed of a Stilling Basin [PDF]
مهندسی منابع آب, 2014 Hydraulic jump type stilling basins with abrupt drop are used to reduce the basin length and to ensure the start of jump at the front of basin immediately downstream of gates.
M.J N, M. SH, S.M K, M. F
doaj
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Optimum take-off angle in the standing long jump [PDF]
, 2005 The aim of this study was to identify and explain the optimum projection angle that maximises the distance achieved in a standing long jump. Five physically active males performed maximum-effort jumps over a wide range of take-off angles, and the jumps ...
Wakai, M +3 more
core +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Factors that affect the optimal drop height to drop jump [PDF]
Godisnjak Fakulteta sporta i fizickog vaspitanja, 2015 It is suggested that, in the sports science and practice, it is advisable to conduct training that would enable achievement of adequate acute effects in order to increase the efficiency of training procedures and maximize the adaptive capacity. Drop jump is one of the most commonly used exercise in plyometric method of training. Optimum intensity range
openaire +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source