Results 31 to 40 of about 4,882 (205)

Recognition of high-specificity hERG K+ channel inhibitor-induced arrhythmia in cardiomyocytes by automated template matching

Microsystems & Nanoengineering, 2021
Cardiovascular disease (CVD) is the number one cause of death in humans. Arrhythmia induced by gene mutations, heart disease, or hERG K+ channel inhibitors is a serious CVD that can lead to sudden death or heart failure.
Hao Wang, Hongbo Li, Xinwei Wei, Tao Zhang, Yuting Xiang, Jiaru Fang, Peiran Wu, Xi Xie, Ping Wang, Ning Hu   +9 more
doaj   +1 more source

Phytochemical Nanoparticles for the Treatment of Neurological Disorders

Phytochemical Analysis, EarlyView.
ABSTRACT Neurological disorders impose a significant burden on the healthcare systems. The latest published data by WHO indicated that stroke was the second leading cause of death globally in 2020, with Alzheimer's disease (AD) and other dementias in the seventh position.
Touraj Ehtezazi, Satyajit D. Sarker
wiley   +1 more source

Profilaxia antiemética em cirurgia de abdome agudo: estudo comparativo entre droperidol, metoclopramida, tropisetron, granisetron e dexametasona Profilaxis antiemética en cirugía de abdomen agudo: estudio comparativo entre droperidol, metoclopramida, tropisetrón, granisetrón y dexametasona Prophylactic antiemetic therapy for acute abdominal surgery: a comparative study of droperidol, metoclopramide, tropisetron, granisetron and dexamethasone

Revista Brasileira de Anestesiologia, 2008
JUSTIFICATIVA E OBJETIVOS: A incidência de náuseas e vômitos pós-operatórios (NVPO) gira em torno de 30%. A profilaxia de NVPO foi objeto de múltiplos estudos, tanto para tentar diminuir esse problema como para comparar o índice custo-benefício do ...
Víctor Contreras-Domínguez, Paulina Carbonell-Bellolio   +1 more
doaj   +1 more source

Critical insights into the potential risks of antipsychotic drugs to fish, including through effects on behaviour

Biological Reviews, EarlyView.
ABSTRACT Antipsychotic drugs (APDs) are a diverse class of neuroactive pharmaceuticals increasingly detected in surface and ground waters globally. Some APDs are classified as posing a high environmental risk, due, in part, to their tendency to bioaccumulate in wildlife, including fish.
Gabrielle Wasser‐Bennett, A. Ross Brown, Samuel K. Maynard, Stewart F. Owen, Charles R. Tyler   +4 more
wiley   +1 more source

HAS DROPERIDOL AN ATROPINIC EFFECT?

British Journal of Anaesthesia, 1979
The action of droperidol on the tachycardia produced by atropine and on the serum concentration of cholinesterases was observed during balanced anaesthesia. Without atropine, the mean heart rates of patients who received fentanyl plus droperidol were similar. Atropine increased heart rate only in the presence of droperidol (P less than 0.001) (fentanyl
Parmentier, P., Dagnelie, Paul
openaire   +4 more sources

Comparative Safety of Medications for Severe Agitation: A Geriatric Emergency Department Guidelines 2.0 Systematic Review

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Managing undifferentiated, severe agitation in older adults may require antipsychotic or sedative medications to prevent harm to self or others. Unfortunately, these medications are associated with serious adverse events in older adults, and little is known about their comparative safety.
Martin F. Casey, Natalie M. Elder, Alexander Fenn, Joshua Niznik, Danya Khoujah, Jon B. Cole, Zachary Cardon, Ming Ding, Naira Goukasian, Elizabeth Moreton, Jennifer L. Koehl, Phillip D. Magidson, Rachel M. Skains, Katren Tyler, Shan W. Liu, on behalf of the Geriatric Emergency Department Guidelines Medication Safety Group, Jane M. Hayes, Katherine Selman, Phraewa Thatphet, Kazuki Toda, Bryan D. Hayes, Sangil Lee   +21 more
wiley   +1 more source

Consensus on the Management of Anesthetic Agents During Digestive Motility Measurements and Proposal of a Standardized Protocol for Anesthesia (French Neuro Gastroenterology Group GFNG and Committee of Anesthetic French Experts)

Neurogastroenterology &Motility, EarlyView.
Anesthesia can alter measurements during digestive endoscopies, yet no standardized protocol currently exists. Two expert groups—the French Neuro‐Gastroenterology Group (GFNG) and anesthesiologists—used the Delphi method to reach a consensus on which drugs have an influence (91 amendments), ultimately resulting in a proposed anesthesia protocol (28 ...
Domitille Renard, Thomas Clavier, Osama Abou‐Arab, Gérard Amarenco, Emmanuel Besnier, Alice Blet, Matthieu Boisson, Charlène Brochard, Benoit Coffin, Audrey De Jong, Denis Frasca, Marc Garnier, Aurelie Gouel, Jérémie Jacques, Arthur James, Yoann Launey, Anne‐Marie Leroi, Chloé Melchior, Daphné Michelet, François Mion, Maxime Nguyen, Emmanuel Rineau, Amélie Rollé, Sabine Roman, Stéphanie Sigaut, Heithem Soliman, Fabien Wuestenberghs, Frank Zerbib, Guillaume Gourcerol, Charlotte Desprez   +29 more
wiley   +1 more source

Assessment of Diverse Solid−State Accelerated Autoxidation Methods for Droperidol

Pharmaceutics, 2022
The present study aimed to investigate methods for accelerating autoxidation of crystalline drugs in the solid-state that can potentially predict real−time stability. Solid droperidol (DPD) was selected as the model drug. A common free−radical initiator,
Jayant Iyer, Isha Saraf, Andrew Ray, Michael Brunsteiner, Amrit Paudel   +4 more
doaj   +1 more source

Guidelines for Enhanced Recovery After Trauma and Intensive Care (ERATIC): Enhanced Recovery After Surgery (ERAS) and International Association for Trauma Surgery and Intensive Care (IATSIC) Society Recommendations: Paper 2: Postoperative and Intensive Care Recommendations

World Journal of Surgery, Volume 49, Issue 8, Page 2029-2054, August 2025.
ABSTRACT Background Enhanced recovery after surgery (ERAS) protocols reduce length of stay, complications, and costs for elective surgical procedures. It remains challenging to implement ERAS concepts in the acute trauma patient due to deranged physiological reserve from the penetrating or blunt trauma producing altered physiology.
Timothy C. Hardcastle, Christine Gaarder, Zsolt Balogh, Scott D'amours, Kimberly A. Davis, Amit Gupta, Shahin Mohseni, Paal A. Naess, Shanisa Naidoo, Tarek Razek, Simon Robertson, Hayaki Uchino, David Zonies, Jade Whing, Michael J. Scott   +14 more
wiley   +1 more source