Results 51 to 60 of about 4,974 (154)

Quantifying Risk of Delayed QT Prolongation of Ipatasertib in Preclinical and Clinical Studies in Cancer Patients

Clinical and Translational Science, Volume 18, Issue 7, July 2025.
ABSTRACT QTc prolongation has been associated with torsades de pointes (TdP) and also with other cardiac diseases. We investigated the effect of ipatasertib, a selective serine/threonine kinase (AKT, protein kinase B) inhibitor, on preclinical models of QTc prolongation as well as across two clinical studies. Preclinical in vitro studies suggested that
Victor Poon, Dhruvitkumar Sutaria, Rodney Prell, Wendy Halpern, Lisa Wong, Adam Harris, Justin Wilkins, Kenta Yoshida, Rucha Sane   +8 more
wiley   +1 more source

18F‐Fallypride: A Valuable Agent for Islet Cell‐Targeted Imaging

Organ Medicine, Volume 2, Issue 2, Page 97-102, June 2025.
The visualization of islets can be a useful tool for studying islet cell function and monitoring islet cell transplantations, to assess the practicability of 18F‐fallypride (a dopamine D2 receptor imaging agent) for islet cell‐targeted imaging through islet cell and animal experiments.
Yangyang Qin, Xiaowei Lu, Kaiwei Xu, Ruoyu Wu, Wenqi Shen, Jiajing Ni, Jianhua Wang   +6 more
wiley   +1 more source

Could Flumazenil Be Used Pre‐hospital by Intramuscular Injection for Coma due to Mixed Drug Overdose Not Responding to Naloxone?: A Systematic Review of the Evidence

Basic &Clinical Pharmacology &Toxicology, Volume 136, Issue 3, March 2025.
ABSTRACT Background/Rationale Benzodiazepine‐involved overdose deaths are increasing. Flumazenil is rarely used due to fear of seizures; however, the risk benefit may favour its use. Flumazenil is licensed for intravenous (IV) use, but intramuscular (IM) treatment would be required pre‐hospital.
Ilinca Farcas, Lisa Schölin, Michael Eddleston   +2 more
wiley   +1 more source

Ketamine for rapid control of hyperactive delirium with severe agitation. A retrospective comparison study

JEM Reports
Background: The agitated patient represents a very large clinical problem for the work of the emergency department. The therapeutic goal is rapid symptom control while ensuring maximum patient safety.
Beatrice Borreani, Annalisa Belluti, Francescopaolo D'Adamo, Luca Acquarone, Cristina Cocino, Paolo Canepa, Francesco Quaglia, Martina D'Antoni, Andrea Alienda, Alessandro Riccardi   +9 more
doaj   +1 more source

Acute care of cyclic vomiting syndrome and cannabinoid hyperemesis syndrome in the home and emergency department

Neurogastroenterology &Motility, Volume 37, Issue 3, March 2025.
Abstract Background Cyclic vomiting syndrome (CVS) and cannabinoid hyperemesis syndrome (CHS) are both characterized by episodic, acute transitions from asymptomatic states to highly symptomatic states of nausea, repetitive vomiting, and often severe abdominal pain.
David J. Levinthal, Blynda Killian, Robert M. Issenman   +2 more
wiley   +1 more source

Extended release granisetron: Review of pharmacologic considerations and clinical role in the perioperative setting

Saudi Journal of Anaesthesia, 2019
In this review, we evaluate recent literature on use of ER granisetron in clinical practice as compared with current antiemetics and describe its potential uses for perioperative PONV prophylaxis and treatment.
Anh L Ngo, Vwaire Orhurhu, Ivan Urits, Edwin O Delfin, Medha Sharma, Mark R Jones, Omar Viswanath, Richard D Urman   +7 more
doaj   +1 more source

Construction and Development of an Enhanced Recovery After Surgery Program for the Surgical Management of Patients With Spinal Metastasis: A Modified Delphi Study

Orthopaedic Surgery, Volume 17, Issue 3, Page 939-952, March 2025.
ABSTRACT Objective As an effective treatment for spinal metastasis (SM), ERAS protocol can significantly reduce the length of hospital stay and complications in patients. Establishing an ERAS program for perioperative care after SM surgery is a clinical problem that needs to be addressed urgently. We aimed to develop an Enhanced Recovery After Surgery (
Fanjie Li, Wenlong Yu, Haohan Zhou, Fan Zhang, Zihuan Zhou, Qiang Gao, Xin Gao, Luosheng Zhang, Yinjie Yan, Quan Huang, Xinghai Yang, Peilin Chu, Mengchen Yin   +12 more
wiley   +1 more source

Physicochemical stability of ternary admixtures of butorphanol, ketamine, and droperidol in polyolefin bags for patient-controlled analgesia use

Drug Design, Development and Therapy, 2016
Baoxia Fang,1 Linhai Wang,2 Junfeng Gu,3 Fuchao Chen,1 Xiao-ya Shi1 1Department of Pharmacy, Dongfeng Hospital, 2Department of Pharmacy, 3Department of Anesthesiology, Renmin Hospital, Hubei University of Medicine, Hubei, People’s Republic of
Fang BX, Wang LH, Gu JF, Chen FC, Shi XY
doaj  

Review article: Scoping review of interventions that reduce mechanical restraint in the emergency department

Emergency Medicine Australasia, Volume 37, Issue 1, February 2025.
Mechanical restraints are known to be associated with many undesirable outcomes in clinical settings. We examined the literature and found that several interventions haveworked to reduce mechanical restraint rates in emergency departments. Abstract Objective Mechanical restraints are known to be associated with many undesirable outcomes in clinical ...
Joseph Lee, Daiv J Lown, Patrick J Owen, Judith Hope   +3 more
wiley   +1 more source

Endoscopic ultrasound‐guided gastrojejunostomy with wire endoscopic simplified technique: Move towards benign indications (with video)

Digestive Endoscopy, Volume 37, Issue 2, Page 167-175, February 2025.
Objectives Endoscopic ultrasound‐guided gastrojejunostomy (EUS‐GJ) is an alternative to duodenal stenting and surgical GJ (SGGJ) in malignant gastric outlet obstruction (MGOO). European Society of Gastrointestinal Endoscopy guidelines restricted EUS‐GJ for MGOO only, because of misdeployment.
Jean‐Michel Gonzalez, Sohaib Ouazzani, Geoffroy Vanbiervliet, Mohamed Gasmi, Marc Barthet   +4 more
wiley   +1 more source