Results 71 to 80 of about 327,401 (350)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

SNEDDS Containing Poorly Water Soluble Cinnarizine; Development and in Vitro Characterization of Dispersion, Digestion and Solubilization

Pharmaceutics, 2012
Self-Nanoemulsifying Drug Delivery Systems (SNEDDSs) were developed using well-defined excipients with the objective of mimicking digested SNEDDSs without the use of enzymes and in vitro lipolysis models and thereby enabling studies of the morphology and
Anne T. Larsen, Anette Müllertz, Ragheb Abu-Rmaileh, Bertil Abrahamsson, Jesper Østergaard, Anayo Ogbonna   +5 more
doaj   +1 more source

Cloud microphysical effects of turbulent mixing and entrainment

, 2012
Turbulent mixing and entrainment at the boundary of a cloud is studied by means of direct numerical simulations that couple the Eulerian description of the turbulent velocity and water vapor fields with a Lagrangian ensemble of cloud water droplets that ...
A. Lanotte, A.B. Kostinski, A.M. Blyth, A.N. Kolmogorov, B. Knaepen, Bipin Kumar, D. Lamb, G. Steinfeld, H. Siebert, J. Latham, J. Schumacher, J. Schumacher, J.B. Jensen, J.P. Mellado, Jörg Schumacher, K. Lehmann, M. Andrejczuk, M. Andrejczuk, M. Andrejczuk, M.B. Baker, P.A. Vaillancourt, R.A. Shaw, R.R. Rogers, Raymond A. Shaw, S. Wang, V. Eswaran   +25 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Nucleation of stable cylinders from a metastable lamellar phase in a diblock copolymer melt [PDF]

, 2003
The nucleation of a droplet of stable cylinder phase from a metastable lamellar phase is examined within the single-mode approximation to the mean-field Landau–Brazovskii model for diblock copolymer melts.
Shi, An-Chang, Wang, Zhen-Gang, Wickham, Robert A.   +2 more
core   +1 more source

This Is Not a Myeloproliferative Neoplasm…

Pediatric Blood &Cancer, EarlyView.
Stephanie Juané Kennedy
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Droplet Size Distribution Characteristics of Aerial Nozzles by Bell206L4 Helicopter under Medium and Low Airflow Velocity Wind Tunnel Conditions and Field Verification Test

Applied Sciences, 2020
To investigate the spray atomization characteristics of aerial nozzles adapted to manned agricultural helicopters under medium-low airflow velocity (0 to 27.8 m/s) conditions, the droplet size test was carried out in both wind tunnel and field tests.
Weixiang Yao, Yubin Lan, W. Clint Hoffmann, Jiyu Li, Shuang Guo, Huihui Zhang, Juan Wang   +6 more
doaj   +1 more source

Droplet activation, separation, and compositional analysis: laboratory studies and atmospheric measurements [PDF]

, 2011
Droplets produced in a cloud condensation nuclei chamber (CCNC) as a function of supersaturation have been separated from unactivated aerosol particles using counterflow virtual impaction.
Cziczo, Daniel J., Hiranuma, Naruki, Kohn, Monika, Nelson, Danny A., Pekour, Mikhail S., Shilling, John E.   +5 more
core