Results 91 to 100 of about 3,583,136 (389)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

How robust is the ring stain for evaporating suspension droplets? [PDF]

open access: yes, 2013
The ring stain is commonly seen when droplets containing particles, such as coffee, are left to dry on a surface: a pinned contact line leads to outward radial flow, which is enhanced by the diverging evaporative flux at the contact line.
Fairhurst, DJ, Msambwa, Y, Ouali, FF
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

On the modeling of viscoelastic droplet impact dynamics [PDF]

open access: yes, 2014
This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the ...
4th Micro and Nano Flows Conference (MNF2014)   +4 more
core  

Development of a Multiphase Photon Monte Carlo Method for Spray Combustion and its Application in High-pressure Conditions [PDF]

open access: yes, 2017
In this work the development of a multiphase photon Monte Carlo (PMC) method with a focus on resolving radiative heat transfer in combustion simulations is presented.
Cai, Jian   +2 more
core   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Droplet Transfer Modes Identification in MIG Welding Process Based on a Human Auditory Model

open access: yesJournal of Mechanical Engineering, 2019
: To identify the droplet transfer modes in a strong noise-interfered MIG welding process, a welding arc sound pattern recognition method based on human auditory model is proposed.
Gao Yanfeng   +4 more
semanticscholar   +1 more source

Function-led design of multifunctional stimuli-responsive superhydrophobic surface based on hierarchical graphene-titania nanocoating

open access: yes, 2017
Multifunctional smart superhydrophobic surface with full-spectrum tunable wettability control is fabricated through the self-assembly of the graphene and titania nanofilm double-layer coating.
Liu, Yang
core  

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