We develop an ultrasensitive, high‐accuracy multiplex protein detection platform integrating high‐throughput single‐molecule protein detection with proximity ligation. Using paired DNA barcodes, this platform breaks the digital immunoassay multiplexing ceiling imposed by cross‐reactivity and fluorescence spectral overlap, providing a broadly accessible
Chi‐Chia Wang, Emily Dorsey, Connie Wu
wiley +2 more sources
An evaluation of uncertainty quantification methods and measures for deep learning outcome prediction models in head and neck cancer radiotherapy. [PDF]
MacRae DC +10 more
europepmc +1 more source
Daily‐Life, Sensor‐Derived Tremor Measures Are Sensitive to Progression in Early Parkinson's Disease
Objective Sensitive outcome measures are critical for evaluating the efficacy of novel treatments for Parkinson's disease (PD). In this study, we assess the sensitivity to change of sensor‐derived daily‐life tremor measures over 2 years in unmedicated and medicated persons with early PD.
Nienke A. Timmermans +10 more
wiley +1 more source
Beyond campaigns: a national mixed-methods study on advancing routine HPV vaccination in Lesotho. [PDF]
Zbelo M +5 more
europepmc +1 more source
Miniaturized Conductometric Biosensor for Rapid Detection of TNF‐α in Saliva
A miniaturized conductometric sensor detects TNF‐α at femtomolar levels with high selectivity. The device enables noninvasive testing using pooled human saliva and supports smartphone‐based, real‐time resistance readings. This portable biosensor offers a practical alternative for monitoring TNF‐α, providing new opportunities for diabetes and related ...
Mingjie Yang +8 more
wiley +1 more source
Bayesian optimization for uncertainty-aware prediction of rainfall-induced deformation in embankment dams. [PDF]
Nasser M +5 more
europepmc +1 more source
Sociodemographic and geographic determinants of childhood immunization coverage and equity in Ghana: Analysis of the 2022 demographic and health survey. [PDF]
Saani AT, Azumah GE.
europepmc +1 more source
Piloting a Pragmatic Randomized Controlled Trial on the Effects of Integrated Psychosocial Care in Intensive Care Units (Phase B of the Integrated Psychosocial Care-Pilot Project): Protocol for a Feasibility Study. [PDF]
Heytens H +14 more
europepmc +1 more source
Purpose To systematically review the literature to evaluate complications and patient‐reported outcome measures (PROMs) after hip arthroscopy in patients with femoroacetabular impingement syndrome. Methods Five databases were searched for studies reporting complications and PROMs after hip arthroscopy in patients with femoroacetabular impingement ...
Frederik Nicolai Foldager +6 more
wiley +1 more source
scZiva: imputation method for single-cell RNA-seq data with zero-inflated variational autoencoder. [PDF]
Vo LT, Le VV, Ha QT, Nguyen AQ.
europepmc +1 more source

