Results 41 to 50 of about 5,909 (283)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Impact of Damaged Dropper on Pantograph–Catenary Current Collection Quality in High-Speed Railways

open access: yesInventions
The regularity of the catenary system and the stability of pantograph–catenary interaction are crucial for ensuring continuous and stable current collection quality in high-speed trains.
Caizhi Yang   +7 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Plastic Pipette/Dropper

open access: yes, 2018
This image illustrates a plastic pipette or a dropper. This laboratory equipment is used in Introduction to Cell Biology: Biology 107 and Molecular Genetics and Heredity: Biology 207.
University of Alberta, Department of Biological Sciences
core   +1 more source

Lord Kelvin's atmospheric electricity measurements [PDF]

open access: yesHistory of Geo- and Space Sciences, 2013
Lord Kelvin (William Thomson) made important contributions to the study of atmospheric electricity during a brief but productive period from 1859–1861. By 1859 Kelvin had recognised the need for "incessant recording" of atmospheric electrical parameters,
K. L. Aplin, R. G. Harrison
doaj   +1 more source

DESAIN DRONE DROPPER UNTUK MENJAGA PERFORMA MOBIL DAN MENGURANGI DENGUNGAN AKIBAT FREE FLOW EXHAUST PADA TOYOTA YARIS 2NR-FE

open access: yes, 2022
Sistem pembuangan gas dirancang untuk mampu meredam suara bising yang berpusat pada mesin kendaraan. Kebisingan yang ditimbulkan oleh pemasangan free flow exhaust dapat menyebabkan banyak dampak buruk pada kesehatan pengendara.
Yusuf, Billy   +2 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Effect of the farming intensification on health-promoting compounds in the meat of the Mediterranean mussel Mytilus galloprovincialis

open access: yesAquaculture Reports
This study investigated the effect of increasing levels of farming intensification on some health-promoting compounds present in the meat of the Mediterranean mussel Mytilus galloprovincialis in the Northern Coastal Area of Gargano, Italy, during the ...
Antonella della Malva   +3 more
doaj   +1 more source

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