Results 41 to 50 of about 113,534 (232)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

QoS provisioning for Composite Burst Assembly with Burst Segmentation in Optical Burst Switching (OBS) Networks [PDF]

Kirkuk Journal of Science, 2015
Optical Burst Switching (OBS) is one of the suggested that switching paradigms be used in Internet-Protocol over Wavelength Division Multiplexing (IP over WDM) networks along with Optical Circuit Switching (OCS) and Optical Packet Switching (OPS).
Adnan I. Saleh
doaj   +1 more source

A Sketch-Based Fine-Grained Proportional Integral Queue Management Method

Axioms, 2023
The phenomenon “bufferbloat” occurs when the buffers of the network intermediary nodes fill up, causing long queuing delays. This has a significant negative impact on the quality of service of network applications, particularly those that are sensitive ...
Haiting Zhu, Hu Sun, Yixin Jiang, Gaofeng He, Lu Zhang, Yin Lu   +5 more
doaj   +1 more source

Effect of dispersion on indistinguishability between single-photon wave-packets

, 2020
With propagating through a dispersive medium, the temporal-spectral profile of laser pulses should be inevitably modified. Although such dispersion effect has been well studied in classical optics, its effect on a single-photon wave-packet, i.e., the ...
Rui-Ming Zhang (17517105), Zhen Wang (72451), Qiang Zhou (29805), You Wang (312086), Chen-Zhi Yuan (17517102), Hao Li (31608), Guang-Wei Deng (1511350), Li-Xing You (14382015), Si Shen (3476153), Peng Wu (210686), He-Qing Wang (17517108), Hai-Zhi Song (9926655), Guang-Can Guo (1511335), Yun-Ru Fan (17517099)   +13 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Dynamically reconfigurable optical packet switch (DROPS)

Optics Express, 2006
A novel Dynamically Reconfigurable Optical Packet Switch (DROPS) that combines both spectral and spatial switching capabilities is proposed and experimentally demonstrated for the first time. Compared with an Arrayed Waveguide Grating Router (AWGR), the added spatial switching capability provided by the microelectromechanical systems (MEMS) enables ...
Huang, C H, Chou, H F, Bowers, J E, Toudeh-Fallah, F, Gyurek, R   +4 more
openaire   +3 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

The FN quadratic marking/dropping probability function [PDF]

, 2009
The gateway queuing performance depends on the marking/dropping probability function chosen. This function plays an important role in managing the gateway buffer.
M. Kadhum, Mohammed, Hassan, Suhaidi
core   +2 more sources

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source