Results 141 to 150 of about 478,575 (316)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Quasi-two-dimensional pseudo-sessile drops

Communications Physics
Sessile drops are ubiquitous and important in technological applications. While dynamics of liquid drops have been studied under confinement, the possibility of creating sessile drops with reduced dimensionality has not been explored.
Tytti Kärki, Into Pääkkönen, Nikos Kyriakopoulos, Jaakko V. I. Timonen   +3 more
doaj   +1 more source

A drop in the bucket.

Genome biology, 2004
With 151 billion dollars, all world-wide AIDS programs could be fully funded for the next 12 years.
openaire   +2 more sources

UV-Spectrophotometric Evaluation of the Stability of Ciprofloxacin Eye Drops at Various Temperature Conditions [PDF]

Ciprofloxacin eye drops, a topical antibiotic for ocular diseases, is commonly obtained “over the counter,” and people are not educated about the importance of storage of the medications, thus interfering with their stability.
Nita Charlotte, Margaret Shanthi, Aniket Kumar, Niranjana Jeba Jeeviha, Mohammed Haris, Gabriella Sharon David   +5 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Drop by drop [PDF]

Nature Chemistry, 2013
openaire   +1 more source

live-drops

, 1971
live aAnd three square meals a day and live-drops in between." "Live-drops?" questioned Trevor with humorous interest./ "Yes, sir, live-drops, mug-ups! A cup of tea any time of the day.PRINTED ITEM DNE-cit G. M.

core  

Liquid Drops [PDF]

, 1939
A general mathematical relation between the life of the drops floating on the surface of the same liquid and the viscosities of the mother liquid and of the surrounding medium is deduced, which is applicable for all viscosities and under all conditions.
Mahajab, L D
core