Results 111 to 120 of about 559,429 (351)

A Subcircuit in the Suprachiasmatic Nucleus Generates Wakefulness

Advanced Science, EarlyView.
This study identifies a sub‐circuit within the circadian pacemaker suprachiasmatic nucleus (SCN) that promotes arousal. This sub‐circuit is labeled by the clock output molecule mWAKE, which suppresses its excitability in a time‐dependent manner. mWAKE‐expressing cells in the SCN (SCNmWAKE cells) project to the subparaventricular zone (SPZ) to mediate ...
Qiang Liu, Sang Soo Lee, Jiali Xiong, Shahin Ahmadi, Benjamin J. Bell, Mehmet F. Keles, Mark N. Wu   +6 more
wiley   +1 more source

Structural Chromosome Variability in Urban and Rural Populations of Drosophila funebris [PDF]

, 1946
N. P. Dubinin, G. G. Tiniakov
openalex   +1 more source

Gut Microbial Genetic Variation Prolongs Host Healthy Longevity and Remodels Metabolome and Proteome in Drosophila Melanogaster

Advanced Science, EarlyView.
This study reveals that specific genetic variations in gut‐residing Saccharomyces cerevisiae significantly extend healthspan and lifespan in Drosophila melanogaster. These mutants rejuvenate aged intestinal metabolism, upregulate mitochondrial proteins, and enhance energy pathways.
Liying Wang, Ziling Yang, Yulu Pang, Xinyue Wu, Xinrong Zhang, Tao Zhu, Xiaoyue Ding, Wei Liu, Yuan Zhou, Pengcheng Zhang, Ying Li, Zuobin Zhu   +11 more
wiley   +1 more source

NADPH Oxidase Inhibition Promotes Brain Resilience by Attenuating Tauopathy and Neuroinflammation in Alzheimer's Disease

Advanced Science, EarlyView.
CRB‐2131, as a novel Nox inhibitor, suppresses brain oxidation, tauopathy, and neuro‐inflammation, thereby preventing death of mature neurons and promoting regeneration of immature neurons. Ultimately, this fosters a resilient brain and protects cognition.
Jihyeon Lee, Seunghwan Sim, Yinglan Jin, Hyejun Park, Eun Young Byeon, Su Jin Kim, Sujin Yun, Hye Eun Lee, Da Un Jeong, Jung Min Suh, In Hye Lee, Ho‐Young Lee, Yongseok Choi, Yun Soo Bae   +13 more
wiley   +1 more source

Amnesiac (AMN) gene and cnc/Nrf2-redox responses in fruit fly model of memory impairment co-administered Solanum leaves and donepezil

Pharmacological Research - Modern Chinese Medicine
Background: Considering that Alzheimer disease (AD) is a disease of multiple etiological theories, there is a continuous quest for multitarget approach for its management. In view of this, combinatory approach using therapeutic drugs and functional foods
Odunayo M. Agunloye, Opeyemi B. Ogunsuyi, Odunayo O. Oluokun, Ganiyu Oboh   +3 more
doaj   +1 more source

GENETIC AND ENVIRONMENTAL FACTORS AFFECTING THE DEVELOPMENT OF THE SEX-COMBS OF DROSOPHILA MELANOGASTER [PDF]

, 1937
J. Dale Combs
openalex   +1 more source

EETs Reduction Contributes to Granulosa Cell Senescence and Endometriosis‐Associated Infertility via the PI3K/AKT/mTOR Signaling Pathway

Advanced Science, EarlyView.
1) 14, 15‐EET levels were decreased in ovarian granulosa cells, follicular fluid, peritoneal fluid from endometriosis patients. 2) EETs reduction in endometriosis follicular fluid aggravated granulosa cell senescence. 3) ROS reduced 14, 15‐EET levels by upregulating EPHX2 through a mechanism involving histone methylation modification.
Xiang Lin, Weijia Gu, Xiaomei Tong, Mengru Lai, Yi Zhang, Na Liu, Xiaoying Jin, Chao Li, Dong Huang, Feng Zhou, Yongdong Dai, Songying Zhang   +11 more
wiley   +1 more source

Intra-sexual selection in Drosophila [PDF]

, 1948
A. J. BATEMAN
openalex   +1 more source

TWF2 Drives Tumor Progression and Sunitinib Resistance in Renal Cell Carcinoma through Hippo Signaling Suppression

Advanced Science, EarlyView.
Twinfilin actin‐binding protein (TWF2) is upregulated in sunitinib‐resistant renal cell carcinoma (RCC) cells, where it interacts with YAP and protects YAP from degradation. Stabilized YAP translocates into the nucleus and activates transcription of target genes, promoting RCC progression and drug resistance.
Liangmin Fu, Wuyuan Liao, Youyan Tan, Hansen Lin, Kun Ye, Xinwei Zhou, Mingjie Lin, Kangbo Huang, Minyu Chen, Jietao Wei, Haoqian Feng, Yuhang Chen, Jinwei Chen, Bohong Guan, Shan Li, Zhengkun Zhang, Anze Yu, Zihao Feng, Lizhen Zhang, Guannan Shu, Jun Lu, Wei Chen, Yihui Pan, Jiefeng Yang, Junhang Luo, Li Luo   +25 more
wiley   +1 more source

The effect of Clitoria ternatea L. flowers-derived silver nanoparticles on A549 and L-132 human cell lines and their antibacterial efficacy in Caenorhabditis elegans in vivo

Hybrid Advances
Clitoria ternatea L. flowers were used for the green synthesis of silver nanoparticles (CT-AgNPs) with a focus on their anticancer and antimicrobial properties. The CT-AgNPs were characterized using a variety of techniques, including UV–Vis spectroscopy,
Sapam Riches Singh, Bushrabanu Kittur, Santosh Mallikarjun Bhavi, Bothe Thokchom, Akshata Choudhari Padti, Shivanand S. Bhat, Sukesh Kumar Bajire, Rajesh P. Shastry, B.S. Srinath, Mika Sillanpää, B.P. Harini, Ramesh Babu Yarajarla   +11 more
doaj   +1 more source