Results 121 to 130 of about 710,573 (349)
Advances in cancer research, 2009 Myc genes play a major role in human cancer, and they are important regulators of growth and proliferation during normal development. Despite intense study over the last three decades, many aspects of Myc function remain poorly understood. The identification of a single Myc homolog in the model organism Drosophila melanogaster more than 10 years ago ...
openaire +3 more sources
A Subcircuit in the Suprachiasmatic Nucleus Generates Wakefulness
Advanced Science, EarlyView.This study identifies a sub‐circuit within the circadian pacemaker suprachiasmatic nucleus (SCN) that promotes arousal. This sub‐circuit is labeled by the clock output molecule mWAKE, which suppresses its excitability in a time‐dependent manner. mWAKE‐expressing cells in the SCN (SCNmWAKE cells) project to the subparaventricular zone (SPZ) to mediate ...
Qiang Liu +6 more
wiley +1 more source
A Novel Genetic Screen Identifies Modifiers of Age-Dependent Amyloid β Toxicity in the Drosophila Brain [PDF]
, 2017 The accumulation of amyloid β peptide (Aβ) in the brain of Alzheimer's disease (AD) patients begins many years before clinical onset. Such process has been proposed to be pathogenic through the toxicity of Aβ soluble oligomers leading to synaptic ...
Belfiori Carrasco, Lautaro Francisco +5 more
core +1 more source
A FURTHER ANALYSIS OF LOCI IN THE SO-CALLED "INERT REGION" OF THE X CHROMOSOME OF DROSOPHILA [PDF]
, 1937 Hermann J. Müller +3 more
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Genomic Insights into the Origin, High Fecundity and Environmental Adaptation of Hu Sheep
Advanced Science, EarlyView.The Hu sheep diverged from the Small‐tailed Han sheep ≈1330 years ago, and subsequently migrated from northern to warm and humid southern regions. The genes BMPR1B, UNC5C, and GRID2 play a synergistic role in the superior reproductive traits of Hu sheep.
Zexuan Liu +12 more
wiley +1 more source
, 2018 Developing whole-brain emulation (WBE) technology would provide immense benefits across neuroscience, biomedicine, artificial intelligence, and robotics.
Collins, Logan Thrasher
core +1 more source
A small RNA response at DNA ends in Drosophila [PDF]
, 2012 Small RNAs have been implicated in numerous cellular processes, including effects on chromatin structure and the repression of transposons. We describe the generation of a small RNA response at DNA ends in Drosophila that is analogous to the recently ...
Böttcher, Romy +2 more
core +1 more source
THE INFLUENCE OF THE INTENSITY OF LIGHT ON THE RATE OF GROWTH AND DURATION OF LIFE OF DROSOPHILA [PDF]
, 1925 John H. Northrop
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Targeting Seipin to Alleviate Hepatic Steatosis in Zebrafish (Danio Rerio)
Advanced Science, EarlyView.Seipin plays a crucial role in lipid metabolism. Seipin overexpression ameliorates high‐fat‐diet‐induced hepatic steatosis and enhances growth in zebrafish. Mechanistically, Seipin interacts with Plin2 to promote Plin2 degradation and enhances phosphatidylcholine synthesis via Seipin/CCTα/CHPT interactions.
Weijia Li +6 more
wiley +1 more source
A NEW TYPE OF TRANSLOCATION IN DROSOPHILA MELANOGASTER [PDF]
, 1931 Marcus M. Rhoades
openalex +1 more source