Results 131 to 140 of about 710,573 (349)

Structural Basis of GABAB Receptor Activation during Evolution

open access: yesAdvanced Science, EarlyView.
This study explores the structural and functional mechanisms of the drosophila GABAB receptor, a key role in neurotransmission. Using cryo‐EM, the research reveals how the receptor's activation differs from its human counterpart, highlighting unique evolutionary features.
Guofei Hou   +14 more
wiley   +1 more source

Antioxidant and anti-diabetic potential of the green synthesized silver nanoparticles using Martynia annua L. root extract

open access: yesNano TransMed
The weed Martynia annua traditionally known as Kakanasika is annual herbaceous plant known for its multiple medicinal properties such as anthelmintic, analgesic, antipyretic, antibacterial, anti-convulsant, anti-fertility, antinociceptive, antioxidant ...
Megha B. Abbigeri   +5 more
doaj  

Effect of Itrifal Muqawwi-e-Dimagh (a polyherbal drug) on the transgenic Drosophila model of Parkinson's Disease

open access: yesPhytomedicine Plus, 2021
Background: Parkinson's Disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta of the mid brain which leads to the depletion of dopamine levels.
Yasir Hasan Siddique   +4 more
doaj  

Biomolecular Interaction Prediction: The Era of AI

open access: yesAdvanced Science, EarlyView.
This review offers a thorough examination of recent progress in deep learning for predicting biomolecular interactions, including those involving proteins, nucleic acids, and small molecules. It covers data processing strategies, representative model architectures, and evaluation metrics, while highlighting current methodological limitations.
Haoping Wang, Xiangjie Meng, Yang Zhang
wiley   +1 more source

A study on the antioxidant, cytotoxicity, and coagulation potential of carbon quantum dots derived from the leaves of Lagerstroemia speciosa

open access: yesHybrid Advances
The green synthesis of carbon quantum dots (CQDs) from natural sources offers a sustainable approach in nanotechnology. In this study, CQDs were synthesized from Lagerstroemia speciosa leaves (LS-CQDs) and extensively characterized for their optical ...
Sapam Riches Singh   +9 more
doaj  

In the quest for the ideal sweetener: Aspartame exacerbates selected biomarkers in the fruit fly (Drosophila melanogaster) model of Alzheimer's disease more than sucrose

open access: yesAging Brain, 2023
This study evaluated the effect of dietary inclusions of aspartame and sucrose on some selected behavioral and biochemical indices linked with Alzheimer's disease in a transgenic fruit fly (Drosophila melanogaster) model expressing human amyloid ...
Bukola Christiana Adedayo   +3 more
doaj  

Dynamic eIF3‐S6 Phase Separation Switch Instructed by m6A Modification Drives the Molting of Locusts

open access: yesAdvanced Science, EarlyView.
This research reveals that reduced m6A modifications during insect molting trigger liquid–liquid phase separation (LLPS) of the m6A reader eIF3‐S6, which binds and stabilizes key molting mRNAs, including EcR and Cht10. Disrupting m6A or LLPS causes cuticle remodeling defects and molting failure, highlighting the synergistic control of gene expression ...
Zhihao Hu   +8 more
wiley   +1 more source

Targeting and regulatory mechanisms in chromosome-wide gene regulation using Drosophila melanogaster as a model organism [PDF]

open access: yes, 2010
Tese de mestrado. Biologia (Biologia Molecular e Genética). Universidade de Lisboa, Faculdade de Ciências, 2010O cromossoma 4 de Drosophila melanogaster é muito heterocromático, sendo rico em DNA satélite e DNA de elementos transposáveis. Apesar das suas
Figueiredo, Ana Margarida Adónis, 1986-
core  

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