Results 141 to 150 of about 913,402 (352)

The genome sequence of Drosophila melanogaster.

Science, 2000
M. Adams, S. Celniker, R. Holt, C. Evans, J. Gocayne, P. Amanatides, S. Scherer, P. Li, R. Hoskins, R. Galle, R. George, S. Lewis, S. Richards, M. Ashburner, S. Henderson, G. Sutton, J. Wortman, M. Yandell, Q. Zhang, L. Chen, R. Brandon, Y. Rogers, R. Blazej, M. Champe, B. Pfeiffer, K. Wan, C. Doyle, E. G. Baxter, G. Helt, C. Nelson, G. Gábor, J. F. Abril, A. Agbayani, H. An, C. Andrews-Pfannkoch, D. Baldwin, R. Ballew, A. Basu, J. Baxendale, L. Bayraktaroglu, E. Beasley, K. Beeson, P. Benos, B. Berman, D. Bhandari, S. Bolshakov, D. Borkova, M. Botchan, J. Bouck, P. Brokstein, P. Brottier, K. C. Burtis, D. Busam, H. Butler, É. Cadieu, A. Center, I. Chandra, J. Cherry, S. Cawley, C. Dahlke, L. Davenport, P. Davies, B. de Pablos, A. Delcher, Z. Deng, A. D. Mays, I. Dew, S. Dietz, K. Dodson, L. Doup, M. Downes, S. Dugan-Rocha, B. Dunkov, P. Dunn, K. Durbin, C. Evangelista, C. Ferraz, S. Ferriera, W. Fleischmann, C. Fosler, A. Gabrielian, N. Garg, W. Gelbart, K. Glasser, A. Glodek, F. Gong, J. H. Gorrell, Z. Gu, P. Guan, M. Harris, N. Harris, D. Harvey, T. J. Heiman, J. Hernandez, J. Houck, D. Hostin, K. Houston, T. Howland, M. Wei, C. Ibegwam, M. Jalali, F. Kalush, G. Karpen, Z. Ke, J. Kennison, K. Ketchum, B. E. Kimmel, C. Kodira, C. Kraft, S. Kravitz, D. Kulp, Z. Lai, P. Lasko, Y. Lei, A. Levitsky, J. Li, Z. Li, Y. Liang, X. Lin, X. Liu, B. Mattei, T. McIntosh, M. P. McLeod, D. McPherson, G. Merkulov, N. Milshina, C. Mobarry, J. Morris, A. Moshrefi, Stephen M. Mount, M. Moy, B. Murphy, L. Murphy, D. Muzny, D. Nelson, D. Nelson, K. Nelson, K. Nixon, D. Nusskern, J. Pacleb, M. Palazzolo, G. Pittman, S. Pan, J. Pollard, V. Puri, M. G. Reese, K. Reinert, K. Remington, R. Saunders, F. Scheeler, H. Shen, B. Shue, I. Sidén-Kiamos, M. Simpson, M. Skupski, T. Smith, E. Spier, A. Spradling, M. Stapleton, R. Strong, E. Sun, Rob Svirskas, C. Tector, R. Turner, E. Venter, A. H. Wang, X. Wang, Z. Y. Wang, D. Wassarman, G. Weinstock, J. Weissenbach, S. Williams, WoodageT, K. Worley, D. Wu, S. Yang, Q. Yao, J. Ye, R. Yeh, J. Zaveri, M. Zhan, G. Zhang, Q. Zhao, L. Zheng, X. H. Zheng, F. Zhong, W. Zhong, X. Zhou, S. Zhu, X. Zhu, H. Smith, R. Gibbs, E. Myers, G. Rubin, J. Venter   +194 more
semanticscholar   +1 more source

Microvascular Health as a Key Determinant of Organismal Aging

Advanced Science, EarlyView.
This review spotlights the emerging field of vascular aging, providing a comprehensive and critical overview of the molecular processes and clinical manifestations of vascular dysfunction during aging. By combining basic angioscience concepts with a critical analysis of innovative pre‐clinical aging models and lifestyle interventions, it offers a ...
Mattia Cenciarini, Andrea Uccelli, Francesca Mangili, Myriam Grunewald, Simone Bersini   +4 more
wiley   +1 more source

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

Nature, 1997
R. Medzhitov, P. Preston-Hurlburt, C. Janeway   +2 more
semanticscholar   +1 more source

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source

Effect of Withania somnifera leaf extract on the dietary supplementation in transgenic Drosophila model of Parkinson’s disease

All Results Journals: Biol, 2015
The role of Withania somnifera L. leaf extract was studied on the transgenic Drosophila model flies expressing normal human alpha synuclein (h-αS) in the neurons. The leaf extract was prepared in acetone and was subjected to GC-MS analysis. W.
YASIR HASAN SIDDIQUE, Syed Faiz Mujtaba, Mohammad Faisal, Falaq Naz, Smita Jyoti   +4 more
doaj  

Stabilized Ion Selectivity Corrects Activation Drift in Kalium Channelrhodopsins

Advanced Science, EarlyView.
As newly emerged optogenetic tools, potassium channelrhodopsins (KCRs) can drift from inhibition to activation during illumination as K⁺ selectivity declines. It is shown that both the absolute K⁺/Na⁺ permeability ratio and its stability over time govern this drift, identify KCR1‐C29D as a reliably inhibitory variant, and outline design principles for ...
Xiao Duan, Chong Zhang, Stanislav Ott, Zhiyi Zhang, Christiane Ruse, Sven Dannhäuser, Robert Jacobi, Nadine Ehmann, Divya Sachidanandan, Georg Nagel, Manfred Heckmann, Robert J. Kittel, Alexander Gottschalk, Adam Claridge‐Chang, Shiqiang Gao   +14 more
wiley   +1 more source

The case for emulating insect brains using anatomical "wiring diagrams" equipped with biophysical models of neuronal activity

, 2018
Developing whole-brain emulation (WBE) technology would provide immense benefits across neuroscience, biomedicine, artificial intelligence, and robotics.
Collins, Logan Thrasher
core   +1 more source

The host defense of Drosophila melanogaster.

Annual Review of Immunology, 2007
B. Lemaître, J. Hoffmann
semanticscholar   +1 more source

DCAF12 Ubiquitin Ligase Promotes Lung Cancer Metastasis by Modulating the TRiC/CCT Chaperonin Complex

Advanced Science, EarlyView.
This study elucidates how DCAF12 facilitates non‐degradative ubiquitination to stabilize TRiC/CCT, thereby enhancing the folding capacity of chaperonins. This mechanism promotes the maturation of cytoskeletal proteins and activates key oncogenic drivers, including YAP, STAT3, and mTOR, ultimately driving metastatic progression in lung cancer.
Zhenyi Wang, Huanhuan Huang, Kaizong Huang, Xiaowen Cui, Leilei Wu, Renyu Lin, Zhe Zhao, Hua Chen, Cheng Zheng, Weilin Jin, Song Chen, Jiayan Chen, Yaping Xu, Dongping Wei   +13 more
wiley   +1 more source

Male remating in Drosophila ananassae: evidence for interstrain variation for remating time and shorter duration of copulation in second mating [PDF]

, 2000
—In Drosophila ananassae, male remating was studied using ten mass culture stocks which were initiated from flies collected from different geographic localities. Male remating occurs at a high fre-quency and varies within narrow limits (84–96 percent) in
Singh, Shree Ram
core