Results 151 to 160 of about 913,402 (352)
Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome
Advanced Science, EarlyView.This study introduces a new hypothesis: exons, introns, and intergenic segments are non‐random projections of the functional layers of 3D structure of chromatin packing domains. Evidence is presented that this “geometric code” may encode volumetric structure, reconciling epigenetic patterns, correlates with oncogenic mutations, acting as a potential ...
Luay M. Almassalha +11 more
wiley +1 more source
A genomic approach to the study of Tribolium castaneum genetics, development & evolution [PDF]
, 2004 During the last decade, Tribolium castaneum has become the insect of choice for comparative genetics and developmental studies outside of drosophilids. Until recently, most molecular studies have focused on the comparative analysis of early development ...
Savard, Joël
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Molecular Insights into Fungal Glycosylphosphatidylinositol Transamidase Complex
Advanced Science, EarlyView.The glycosylphosphatidylinositol (GPI) biosynthesis pathway is critical for antifungal drug development. This study reports three cryo‐electron microscopy structures of fungal GPI transamidase (GPIT), captured in two substrate‐bound states and a novel dimeric assembly.
Zhengkang Hua +12 more
wiley +1 more source
Advanced Science, EarlyView.This study identifies that HOXA1 facilitates transcriptional activity of PITX2 in liquid condensates, resulting in up‐regulation of MCOLN1 and RAB3A followed by lysosomal exocytosis of LGALS1 and IGFBP7 from senescent cells, thus activating AKT signaling and EMT.
Yi Zhou +10 more
wiley +1 more source
Four decades of inversion polymorphism in Drosophila pseudoobscura.
, 1991 Wyatt W. Anderson +9 more
openalex +2 more sources
Targeting and regulatory mechanisms in chromosome-wide gene regulation using Drosophila melanogaster as a model organism [PDF]
, 2010 Tese de mestrado. Biologia (Biologia Molecular e Genética). Universidade de Lisboa, Faculdade de Ciências, 2010O cromossoma 4 de Drosophila melanogaster é muito heterocromático, sendo rico em DNA satélite e DNA de elementos transposáveis. Apesar das suas
Figueiredo, Ana Margarida Adónis, 1986-
core
Advanced Science, EarlyView.This study elucidates a molecular mechanism enabling species coexistence between parasitoid wasps, showing how Asobara japonica uses a set of novel venom proteins to delay host development and exploit older hosts, thereby achieving temporal niche partitioning with Leptopilina drosophilae. Abstract Interspecific competition can drive species coexistence
Junwei Zhang +11 more
wiley +1 more source
Discrete Small RNA-Generating Loci as Master Regulators of Transposon Activity in Drosophila
Cell, 2007 J. Brennecke +6 more
semanticscholar +1 more source
Dual Disruption of the Immune Cytokine Spätzle Facilitates Fungal Infection of Diverse Insect Hosts
Advanced Science, EarlyView.The Toll pathway is essential for insect defense against fungal pathogens. This works reports that fungal parasites employ two divergent virulent effectors to target the Toll receptor ligand Spätzle: a metalloprotease degrading it and a hairpin‐like effector hijacking it to block signal transduction. This dual strategy enables the fungus to kill a wide
Shuangxiu Song +7 more
wiley +1 more source