Results 171 to 180 of about 710,573 (349)

In Silico evaluation of phytoconstituents from Carica Papaya and its anti-hyperglycemic activities on high sucrose-induced oxidative stress in Drosophila melanogaster

open access: yesScientific Reports
Oxidative stress plays a key role in the development of metabolic disorders, such as diabetes. This study investigated the phytoconstituents present in Carica papaya (AECP) using an in silico model, and its anti-hyperglycemic activities on high sucrose ...
Omotade I. Oloyede   +8 more
doaj   +1 more source

Approaches to repurposing reverse transcriptase antivirals in cancer

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
This review highlights the role of reverse transcriptase (RT) inhibition in cellular regulation associated with non‐terminal repeat retrotransposons and endogenous retroviruses. Based on their pleiotropic characteristics, RT inhibitors (RTIs) are discussed as potential anticancer agents.
Richard Head   +2 more
wiley   +1 more source

Linear signaling in the Toll-Dorsal pathway of Drosophila: activated Pelle kinase specifies all threshold outputs of gene expression while the bHLH protein Twist specifies a subset [PDF]

open access: yes, 2002
Differential activation of the Toll receptor leads to the formation of a broad Dorsal nuclear gradient that specifies at least three patterning thresholds of gene activity along the dorsoventral axis of precellular embryos.
Levine, Michael, Stathopoulos, Angelike
core  

Reduced Adult Neurogenesis in Humans Results From a Tradeoff Rather Than Direct Negative Selection

open access: yesBioEssays, EarlyView.
Embryonic radial glia (RG) generate neurons, glial cells, and later adult neural stem cells, which sustain adult neurogenesis (top, left to right). Human‐specific genetic modifications (blue arrow), selected to boost early RG neurogenic activity, may lead to premature RG exhaustion and reduced adult neurogenesis in the human brain (bottom).
David Morizet, Laure Bally‐Cuif
wiley   +1 more source

Defective Ribosome Recycling: A Bridge Between Translation Fidelity, Organelle Dysfunction, and Diseases

open access: yesBioEssays, EarlyView.
The Role of Ribosome Recycling in Human Diseases This diagram highlights how disruptions in ribosome translation and recycling can negatively impact cellular and organismal health. Usually, these processes operate efficiently to maintain cellular protein homeostasis.
Foozhan Tahmasebinia, Zhihao Wu
wiley   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

open access: yesChemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves   +3 more
wiley   +1 more source

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