Results 251 to 260 of about 842,087 (402)

Alk<sup>Tango</sup> reveals a role for Jeb/Alk signaling in the Drosophila heart. [PDF]

open access: yesCell Commun Signal
Wolfstetter G   +9 more
europepmc   +1 more source

STARDEV Study: Neurodevelopmental Trajectory and Long‐Term Outcomes of Patients with Startle Disease/Hyperekplexia

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background Although initial clinical presentation of hyperekplexia/startle disease is well known, data regarding long‐term clinical outcomes is lacking. Objectives We provide a long‐term evaluation from clinical and pharmacological perspectives, focusing on neurodevelopmental trajectory. Methods Twenty‐eight patients from nine French hospitals
Diane Pina   +19 more
wiley   +1 more source

A high throughput method for isolation of plasmatocytes from hemolymph of adult Drosophila. [PDF]

open access: yesPLoS One
Yadav M   +5 more
europepmc   +1 more source

Neurodegenerative and Neurodevelopmental Roles for Bulk Lipid Transporters VPS13A and BLTP2

open access: yesMovement Disorders, EarlyView.
Abstract Background Bridge‐like lipid transfer proteins (BLTPs) mediate bulk lipid transport at membrane contact sites. Mutations in BLTPs are linked to both early‐onset neurodevelopmental and later‐onset neurodegenerative diseases, including movement disorders.
Sarah D. Neuman   +4 more
wiley   +1 more source

Treatment Selection and Prioritization for the EJS ACT‐PD MAMS Trial Platform

open access: yesMovement Disorders, EarlyView.
Abstract Background There are currently no disease‐modifying therapies (DMTs) registered for Parkinson's disease (PD). The Edmond J. Safra Accelerating Clinical Trials in Parkinson Disease (EJS ACT‐PD) initiative will expedite clinical assessment of putative DMTs through a multi‐arm multistage (MAMS) trial, testing several treatments against a common ...
Cristina Gonzalez‐Robles   +29 more
wiley   +1 more source

Light‐Activated Pharmacological Tools for Exploring the Cholinergic System

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni   +5 more
wiley   +1 more source

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