Results 261 to 270 of about 916,058 (404)

Ontogeny of RSPO1, FOXL2, and RUNX1 during ovarian differentiation in the marsupial tammar wallaby

Developmental Dynamics, EarlyView.
Abstract Background RSPO1 and FOXL2 are female sex‐determining genes involved in the differentiation and organization of the ovary in some eutherian mammals. Mutations or loss of function of these genes are associated with partial to full sex reversal in mice, humans, and goats.
Monika R. Paranjpe, Yu Chen, Geoff Shaw, Marilyn B. Renfree   +3 more
wiley   +1 more source

<i>Drosophila</i> Models Reveal NAT Complex Roles in Heart Development and Enable Functional Validation of Congenital Heart Disease Variants. [PDF]

Cells
Zhu JY, Seah H, Lee H, Liu H, Han Z.
europepmc   +1 more source

Robinow syndrome DVL1 variants disrupt morphogenesis and appendage formation in a Drosophila disease model

Developmental Dynamics, EarlyView.
Abstract Background Robinow syndrome is a rare developmental syndrome caused by variants in genes in Wnt signaling pathways. We previously showed that expression of patient variants in Dishevelled 1 (DVL1) in Drosophila and chicken models disrupts the balance of canonical and non‐canonical Wnt signaling.
Gamze Akarsu, Katja R. MacCharles, Kenneth Kin Lam Wong, Joy M. Richman, Esther M. Verheyen   +4 more
wiley   +1 more source

MicroRNA profiling identifies novel regulators of stem cell function in the adult Drosophila intestine. [PDF]

Sci Rep
Sreejith P, Yon J, Lapenta K, Biteau B.
europepmc   +1 more source

Formation and function of intracardiac valve cells in the Drosophila heart [PDF]

, 2017
Kay Lammers, Bettina Abeln, Mirko Hüsken, Christine Lehmacher, Olympia E. Psathaki, Esther Alcorta, Heiko Meyer, Achim Paululat   +7 more
openalex   +1 more source

Single‐cell sequencing reveals potential novel insights into appendage‐patterning and joint‐development in a spider

Developmental Dynamics, EarlyView.
Abstract Background Jointed appendages represent one of the key innovations of arthropods, and thus understanding the development and evolution of these structures is important for the understanding of the evolutionary success of Arthropoda. In this paper, we analyze a cell cluster that was identified in a previous single‐cell sequencing (SCS ...
Brenda I. Medina‐Jiménez, Graham E. Budd, Ralf Janssen   +2 more
wiley   +1 more source

Maturation of GABAergic signalling times the opening of a critical period in Drosophila melanogaster. [PDF]

Sci Rep
Corke J, Radi MH, Landgraf M, Baines RA.
europepmc   +1 more source

Positive selection at sites of chemosensory genes is associated with the recent divergence and local ecological adaptation in cactophilic Drosophila [PDF]

, 2018
Fernando Dı́az, Carson W. Allan, Luciano M. Matzkin   +2 more
openalex   +1 more source

N6-Methyladenine DNA Modification in Drosophila

Cell, 2015
Guoqiang Zhang, Hua Huang, Di Liu, Ying Cheng, Xiaoli Liu, Wenxin Zhang, Ruichuan Yin, Dapeng Zhang, P. Zhang, Jianzhao Liu, Chaoyi Li, Baodong Liu, Yuewan Luo, Yuanxiang Zhu, Ning Zhang, Shunmin He, Chuan He, Hailin Wang, Dahua Chen   +18 more
semanticscholar   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source