Results 121 to 130 of about 100,447 (280)
Soticlestat as an adjunctive therapy in children and young adults with Dravet syndrome
Epilepsia, EarlyView.Overview of the phase 3 trial evaluating soticlestat as adjunctive therapy in children and young adults with Dravet syndrome. Abstract Objective This study evaluated the efficacy, safety, and tolerability of soticlestat as adjunctive therapy in children and young adults with Dravet syndrome (DS).
Joseph Sullivan +14 more
wiley +1 more source
Focal seizures during simulated driving: A pilot study
Epilepsia, EarlyView.Abstract Cars are increasingly equipped with technology that can be used to analyze driver behavior and alertness, often referred to as driver monitoring systems (DMS). Although initially mainly used to track drivers' attention, DMS are now expanding in the hope of detecting additional forms of driver impairment that may jeopardize driving, such as ...
Emma Nilsson +4 more
wiley +1 more source
Epilepsia, EarlyView.Soticlestat as adjunctive therapy for Lennox–Gastaut syndrome. Abstract Objective There remains a need for new treatments for Lennox–Gastaut syndrome (LGS), a developmental and epileptic encephalopathy with a heterogenous patient population that often requires polytherapy. The phase 3, randomized SKYWAY study (NCT04938427) investigated the efficacy and
Renzo Guerrini +15 more
wiley +1 more source
Butorphanol for Post-Operative Analgesia - A Comparative Clinical Study with Ketorolac [PDF]
, 2010 Introduction: Butorphanol, an opioid derivative has been shown to have, in addition to its analgesic properties, several other advantageous effects like antistressor, sedative and anti-shivering action.
Adappa, Karunakara +7 more
core +1 more source
Epilepsia Open, EarlyView.Abstract The SCN1A gene is implicated in a broad spectrum of epilepsy phenotypes, ranging from self‐limited genetic epilepsy with febrile seizures plus (GEFS+) to severe developmental and epileptic encephalopathies such as Dravet syndrome (DS). While fenfluramine (FFA) has demonstrated strong efficacy in DS, its role in SCN1A‐related epilepsies beyond ...
Giovanni B. Dell'Isola +12 more
wiley +1 more source
The Effect of Olanzapine on Craving and Alcohol Consumption
, 2006 Previous studies have indicated that olanzapine decreases craving after a priming dose of alcohol, that craving after a priming dose of alcohol is greater among individuals with the seven-repeat allele of the DRD4 variable number of tandem repeats (VNTR)
Davidson, Dena +6 more
core
Highly purified cannabidiol (CBD) in CDKL5 deficiency disorder (CDD): Open‐label prospective study
Epilepsia Open, EarlyView.Abstract Objective CDKL5 deficiency disorder (CDD) is an early‐onset developmental and epileptic encephalopathy characterized by frequent drug‐resistant seizures, cerebral visual impairment, motor dysfunction, and sleep and gastrointestinal disturbances.
Marco Perulli +12 more
wiley +1 more source
Epilepsia Open, EarlyView.Abstract Objective Sialidosis type I (ST‐1) is an autosomal‐recessive, very rare, progressive lysosomal storage disorder caused by pathogenic variants in NEU1. It is clinically characterized by progressive ataxia, myoclonic seizures (MS), bilateral tonic–clonic seizures (BTCS), and distinctive ophthalmological findings.
Janina Gburek‐Augustat +15 more
wiley +1 more source