Results 1 to 10 of about 12,292,416 (404)
Designing hydrogels for controlled drug delivery
Nature Reviews Materials, 2016 Jianyu Li, David J Mooney
exaly +2 more sources
Natural products in drug discovery: advances and opportunities
Nature reviews. Drug discovery, 2021 Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases.
A. Atanasov +73 more
semanticscholar +1 more source
Engineering precision nanoparticles for drug delivery
Nature reviews. Drug discovery, 2020 In recent years, the development of nanoparticles has expanded into a broad range of clinical applications. Nanoparticles have been developed to overcome the limitations of free therapeutics and navigate biological barriers — systemic, microenvironmental
M. J. Mitchell +5 more
semanticscholar +1 more source
A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug-Repurposing
Nature, 2020 A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has infected over 2.3 million people, led to the death of more than 160,000 individuals
D. Gordon +124 more
semanticscholar +1 more source
Briefings Bioinform., 2021 Cell line drug screening datasets can be utilized for a range of different drug discovery applications from drug biomarker discovery to building translational models of drug response.
D. Maeser, Robert F. Gruener, R. Huang
semanticscholar +1 more source
Deuterium in drug discovery: progress, opportunities and challenges
Nature reviews. Drug discovery, 2023 Substitution of a hydrogen atom with its heavy isotope deuterium entails the addition of one neutron to a molecule. Despite being a subtle change, this structural modification, known as deuteration, may improve the pharmacokinetic and/or toxicity profile
R. D. Di Martino, B. Maxwell, T. Pirali
semanticscholar +1 more source
Nanobiosystems for Antimicrobial Drug-Resistant Infections
Nanomaterials, 2021 The worldwide increased bacterial resistance toward antimicrobial therapeutics has led investigators to search for new therapeutic options. Some of the options currently exploited to treat drug-resistant infections include drug-associated nanosystems ...
Foteini Gkartziou +3 more
doaj +1 more source
The Cancer Cell Line Encyclopedia enables predictive modeling of anticancer drug sensitivity
Nature, 2012 The systematic translation of cancer genomic data into knowledge of tumour biology and therapeutic possibilities remains challenging. Such efforts should be greatly aided by robust preclinical model systems that reflect the genomic diversity of human ...
J. Barretina +60 more
semanticscholar +1 more source
TCMSP: a database of systems pharmacology for drug discovery from herbal medicines
Journal of Cheminformatics, 2014 BackgroundModern medicine often clashes with traditional medicine such as Chinese herbal medicine because of the little understanding of the underlying mechanisms of action of the herbs. In an effort to promote integration of both sides and to accelerate
Jinlong Ru +13 more
semanticscholar +1 more source
Integrated Analysis Reveals the Potential Significance of HDAC Family Genes in Lung Adenocarcinoma
Frontiers in Genetics, 2022 Histone deacetylases comprise a family of 18 genes, and classical HDACs are a promising class of novel anticancer drug targets. However, to date, no systematic study has been comprehensive to reveal the potential significance of these 18 genes in lung ...
Congkuan Song +4 more
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