Results 1 to 10 of about 7,317,150 (261)

Drugging Drug Resistance [PDF]

Cell, 2010
Resistance to anticancer drugs is widely observed in vitro and in cancer patients, but its prevalence is too high to be solely explained by the acquisition of mutations. Sharma et al. (2010) now report that dynamic chromatin modifications may be an independent route to drug resistance in cancer cells that can be reversed by epigenetic drugs.
Anton Berns, Jan-Hermen Dannenberg
openaire   +3 more sources

On Drugs

The Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of Medicine, 2023
AbstractDespite their centrality to medicine, drugs are not easily defined. We introduce two desiderata for a basic definition of medical drugs. It should: (a) capture everything considered to be a drug in medical contexts and (b) rule out anything that is not considered to be a drug.
Baron, Samuel, Linton, Sara, O'Malley, Maureen A.   +2 more
openaire   +3 more sources

Drug-related mutational patterns in hepatitis B virus (HBV) reverse transcriptase proteins from Iranian treatment-Naïve chronic HBV patients [PDF]

, 2013
Background: Immunomodulators and Nucleotide analogues have been used globally for the dealing of chronic hepatitis B virus (HBV) infection. However, the development of drug resistance is a major limitation to their long-term effectiveness.
Abedi, F., Alavian, S.M., Ataei, B., Azad, T.M., Daram, M., Fazeli, Z., Ghamari, S., Goodarzi, Z., Jazayeri, S.M., Judaki, M.A., Kalantari, E., Karimzadeh, H., Keyvani, H., Khedive, A., Mahabadi, M., Mahmoodi, M., Malekzadeh, R., Mansour-Ghanaei, F., Montazeri, G., Moradi, A., Nejatizadeh, A., Norouzi, M., Pourhosseingholi, M.A., Rafatpanah, H., Ramezani, F., Saberfar, E., Saberfiroozi, M., Samimirad, K., Sanei-Moghaddam, I., Sarizadeh, G., Sayad, B., Somi, M.H., Yaran, M., Ziee, M.   +33 more
core   +1 more source

Epigallocatechin-3-Gallate, the Main Polyphenol in Green Tea, Inhibits Porcine Epidemic Diarrhea Virus In Vitro

Frontiers in Pharmacology, 2021
There are currently no licensed drugs against porcine epidemic diarrhea virus (PEDV), but vaccines are available. We identified a natural molecule, epigallocatechin-3-gallate (EGCG), the main polyphenol in green tea, which is effective against infection ...
Changchao Huan, Changchao Huan, Changchao Huan, Weiyin Xu, Weiyin Xu, Weiyin Xu, Bo Ni, Tingting Guo, Haochun Pan, Haochun Pan, Haochun Pan, Luyao Jiang, Luyao Jiang, Luyao Jiang, Lin Li, Lin Li, Lin Li, Jingting Yao, Jingting Yao, Jingting Yao, Song Gao, Song Gao, Song Gao   +22 more
doaj   +1 more source

FOOD AND DRUGS [PDF]

American Journal of Public Health, 1926
Report of Committee on Uniform Standard Milk Ordinance, Conference of State and Territorial Health Officers, 1926-A committee of 4 members, appointed by the 1925 Conference of State and Territorial Health Officers, was instructed to make a careful study of the so-called standard milk ordinance of the United States Public Health Service and submit a ...
openaire   +37 more sources

MGRL: Predicting Drug-Disease Associations Based on Multi-Graph Representation Learning

Frontiers in Genetics, 2021
Drug repositioning is an application-based solution based on mining existing drugs to find new targets, quickly discovering new drug-disease associations, and reducing the risk of drug discovery in traditional medicine and biology.
Bo-Wei Zhao, Bo-Wei Zhao, Bo-Wei Zhao, Zhu-Hong You, Zhu-Hong You, Zhu-Hong You, Leon Wong, Leon Wong, Leon Wong, Ping Zhang, Hao-Yuan Li, Lei Wang, Lei Wang, Lei Wang   +13 more
doaj   +1 more source

Detecting a signal in the noise : Monitoring the global spread of novel psychoactive substances using media and other open source information [PDF]

, 2015
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no ...
Canadian Community Epidemiology Network On Drug Use, Center for Substance Abuse Research, European Monitoring Centre For Drugs And Drug Addiction, Sumnall H   +3 more
core   +1 more source

Drug Use and Drug Policy [PDF]

Journal of Institutional and Theoretical Economics, 2002
Early in the twentieth century the Dutch East Indies (present-day Indonesia) had a government monopoly on the import, refining, and retailing of opium. There were regional differences in opium policy ranging from areas with prohibition to areas where opium use was hardly restricted.
Luijk, Eric W. van, Ours, Jan C. van
openaire   +4 more sources

FOOD AND DRUGS [PDF]

American Journal of Public Health, 1925
The Composition and Decomposition of Eggs-Miscellaneous data are reported on the composition of eggs, including particularly the percentage of fatty acids in fresh and stale egg yolk, analytical constants of the fat of hen's eggs, duck's eggs, and Chinese preserved egg yolk, and the reaction of egg yolk and white to indicators.-R. T.
openaire   +27 more sources

Provenance-Centered Dataset of Drug-Drug Interactions [PDF]

, 2015
Over the years several studies have demonstrated the ability to identify potential drug-drug interactions via data mining from the literature (MEDLINE), electronic health records, public databases (Drugbank), etc.
A Callahan, A Gottlieb, B Mons, DS Wishart, J Lazarou, K Haerian, L Zhang, M Dumontier, NP Tatonetti, P Avillach, P Groth, RL Bushardt, S Vilar, SV Iyer, T Kuhn   +14 more
core   +3 more sources