Results 231 to 240 of about 28,900 (248)
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In-stent Restenosis of drug-eluting Stents
Future Cardiology, 2013Drug-eluting stents (DES) have emerged as an improved alternative to bare-metal stents by demonstrating reduced rates of restenosis and target lesion revascularization. This emergence has led to the unrestricted use of DES for various indications and lesions, and subsequently revealed DES in-stent restenosis as a novel interventional therapeutic ...
Ron Waksman +2 more
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Drug-Eluting Stents in the Elderly [PDF]
Current Treatment Options in Cardiovascular Medicine, 2010 The introduction of drug-eluting stents (DES) in 2003 has had a great impact on the management of coronary artery disease in the United States. The application of DES to older adults, the population with the highest prevalence of and worst prognosis for coronary artery disease, remains relatively more controversial.
Laura Mauri +2 more
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WIREs Nanomedicine and Nanobiotechnology, 2009
AbstractThis paper reviews the development of coronary stents from a polymer scientist's view point, and presents the first results of an interdisciplinary team assembled for the development of new stent systems. Poly(styrene‐b‐isobutylene‐b‐styrene) block copolymer (SIBS), a nanostructured thermoplastic elastomer, is used in clinical practice as the ...
Chris Frethem +8 more
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AbstractThis paper reviews the development of coronary stents from a polymer scientist's view point, and presents the first results of an interdisciplinary team assembled for the development of new stent systems. Poly(styrene‐b‐isobutylene‐b‐styrene) block copolymer (SIBS), a nanostructured thermoplastic elastomer, is used in clinical practice as the ...
Chris Frethem +8 more
openaire +3 more sources
2011
Coronary stents have revolutionized the management of patients with obstructive coronary artery disease. This chapter will review the problems associated with percutaneous coronary intervention when performed using balloon angioplasty and bare-metal stents, before discussing the first and second generation drug-eluting stents (DESs).
Scot Garg +2 more
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Coronary stents have revolutionized the management of patients with obstructive coronary artery disease. This chapter will review the problems associated with percutaneous coronary intervention when performed using balloon angioplasty and bare-metal stents, before discussing the first and second generation drug-eluting stents (DESs).
Scot Garg +2 more
openaire +4 more sources
2013
Advances in the field of stents have revolutionised the treatment of coronary artery diseases. To provide effective treatment for coronary artery disease, a stent has to be deliverable and flexible, cause minimal trauma to the vessel wall, cause minimal inflammatory reaction, endothelialise well, provide scaffolding for the vessel, and finally promote ...
Abraham J. Domb +4 more
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Advances in the field of stents have revolutionised the treatment of coronary artery diseases. To provide effective treatment for coronary artery disease, a stent has to be deliverable and flexible, cause minimal trauma to the vessel wall, cause minimal inflammatory reaction, endothelialise well, provide scaffolding for the vessel, and finally promote ...
Abraham J. Domb +4 more
openaire +2 more sources
Polymers for Drug Eluting Stents
Current Pharmaceutical Design, 2010Currently approved drug eluting stents (DES) consist of a metallic scaffold and an elutable drug dispersed in a polymer matrix that conformally surrounds the struts. These primarily biostable polymers bind the drug to the stent and modulate the elution of the drug into the arterial tissue.
Ted Parker, Robert Falotico, Vipul Dave
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Mathematical Medicine and Biology, 2010
In this study, we consider a family of mathematical models to describe the elution of drug from polymer-coated stents into the arterial wall. Our models include the polymer layer, the media, the adventitia, a possible topcoat polymer layer and atherosclerotic plaque.
McGinty, Sean +3 more
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In this study, we consider a family of mathematical models to describe the elution of drug from polymer-coated stents into the arterial wall. Our models include the polymer layer, the media, the adventitia, a possible topcoat polymer layer and atherosclerotic plaque.
McGinty, Sean +3 more
openaire +4 more sources
The American Journal of Cardiology, 2007
Drug-eluting stents (DESs) held the promise of mitigating, if not abolishing, in-stent restenosis. This led to early adoption and high penetration of DES use in percutaneous coronary intervention (PCI). Outcomes have not demonstrated an improvement in the hard end points of death and myocardial infarction with these devices, but repeat procedures for ...
Tina L. Pinto Slottow, Ron Waksman
openaire +3 more sources
Drug-eluting stents (DESs) held the promise of mitigating, if not abolishing, in-stent restenosis. This led to early adoption and high penetration of DES use in percutaneous coronary intervention (PCI). Outcomes have not demonstrated an improvement in the hard end points of death and myocardial infarction with these devices, but repeat procedures for ...
Tina L. Pinto Slottow, Ron Waksman
openaire +3 more sources
Drug Eluting Stents and Beyond
Current Pharmaceutical Design, 2008The present review discusses the mechanism of late stent thrombosis and its distinction from restenosis and summarizes the advisory note issued by FDA on the proper usage of different treatments available for atherosclerosis. In light of the latest developments, a plethora of new stents have been and continue to be developed globally. Hence, there is a
Ashish Rastogi, Salomon A Stavchansky
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Current Problems in Cardiology, 2006
The introduction and widespread use of coronary stents have been the most important advancement in the percutaneous treatment of coronary artery disease since the introduction of balloon angioplasty. Coronary artery stents reduce the rate of angiographic and clinical restenosis compared to balloon angioplasty.
David R. Holmes +2 more
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The introduction and widespread use of coronary stents have been the most important advancement in the percutaneous treatment of coronary artery disease since the introduction of balloon angioplasty. Coronary artery stents reduce the rate of angiographic and clinical restenosis compared to balloon angioplasty.
David R. Holmes +2 more
openaire +3 more sources