Results 141 to 150 of about 1,289,803 (292)

Programme quality indicators of HIV drug resistance among adolescents in urban versus rural settings of the centre region of Cameroon [PDF]

, 2020
Joseph Fokam, Armanda Nangmo, Carlson Wandum, Désiré Takou, Maria Mercedes Santoro, Anne Esther Njom Nlend, Francis Ndongo Ateba, Paul Koki Ndombo, Nelly Kamgaing, Cedric Kamta, André Essiane, Virginie Lambo, Charles Fokunang, Dora Mbanya, Vittorio Colizzi, Carlo Federico Perno, Alexis Ndjolo   +16 more
openalex   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

ANTIBIOTIC RESISTANCE THREATS IN PATIENTS WITH INDWELLING URINARY CATHETERS: BACTERIAL SPECTRUM, INFECTION RATES AND THE EMERGENCE OF MULTIDRUG RESISTANT AND EXTENSIVELY DRUG RESISTANT STRAINS

, 2020
Milan Potić, Aleksandar Skakić, Miodrag Djordjević   +2 more
openalex   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Challenges and advances in drug resistance and tolerance in cancer. [PDF]

J Exp Clin Cancer Res
Bivona TG, Yanai I, Calabrò F, Mechta-Grigoriou F, Corleone G, Di Martile M, Tocci A, Tocci P, Vaccarella S, Ferriero MC, Alimonti A, Ruppin E, Nisticò P, Bagnato A, Blandino G.   +14 more
europepmc   +1 more source

DYNAMICS OF DRUG RESISTANCE IN M. TUBERCULOSIS DURING THE NEW CORONAVIRUS INFECTION PANDEMIC IN DUSHANBE: THE NEED FOR URGENT MEASURES

, 2022
Z. Kh. Tilloeva, Z.KH. TILLOEVA
openalex   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Distribution and Drug-Resistance Analysis of Uropathogens in Urinary Tract Infections. [PDF]

Can J Infect Dis Med Microbiol
Wu W, Wu Q, Zhong W, Han L.
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Cancer-associated fibroblasts: enablers of tumor drug resistance. [PDF]

J Transl Med
Chen Y, Xi W, Lai X, Xiang L, Zeng A, Song L.   +5 more
europepmc   +1 more source