Results 201 to 210 of about 1,289,803 (292)

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Proteomic Characterization Reveals CYP2S1 as a Mediator of Drug Resistance in PDAC. [PDF]

Pancreas
Thiel V, Nadler WM, Kerner A, Kuhlmann L, Reitberger M, Vorberg T, Schwerd-Kleine P, Noll E, Giese NA, Yen HY, Steiger K, Vogel V, Klein C, Hackert T, Koschny R, Opitz CA, Trumpp A, Sprick MR, Rösli C.   +18 more
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Prevalence of antimalarial drug resistance molecular markers in Makenene, central Cameroon. [PDF]

Int J Parasitol Drugs Drug Resist
Kala-Chouakeu NA, Djoufounna J, Benoit N, Tchuinkam T, Delandre O, Almeras L, Bamou R, Antonio-Nkondjio C, Madamet M, Pradines B.   +9 more
europepmc   +1 more source

Neuropsychiatric Symptoms Mimicking Dementia in a Patient Treated With Imatinib

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Tyrosine kinase inhibitors are the cornerstone of chronic myeloid leukemia treatment. Newer agents have more potency and a broader spectrum of action, but also a higher potential for neuropsychiatric side effects. We present a case of a patient on imatinib who developed progressive cognitive, mood, and behavioral alterations.
Ashley Jones, Samuele Bonomi, Keith E. Stockerl‐Goldstein, Randall J. Bateman   +3 more
wiley   +1 more source

Drug resistance mechanisms in <i>Mycobacterium tuberculosis i</i>nfection and challenges in vaccine development. [PDF]

Front Pharmacol
Zhang S, Cheng J, Tang Y.
europepmc   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Nanoparticle based siRNA therapeutics for ovarian cancer overcoming drug resistance and future directions. [PDF]

Discov Nano
Di Fonte R, Bolognino I, Sommonte F, Serratì S, Fasano R, Arduino I, Iacobazzi RM, Denora N, Perego P, Rossi G, Tosi D, Porcelli L, Azzariti A.   +12 more
europepmc   +1 more source

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source

Screening for heterogeneous drug resistance in tuberculosis and its impact on clinical prognosis: A comprehensive review. [PDF]

iScience
Du X, Shi K, Zhang H, Chong Y.
europepmc   +1 more source