Results 271 to 280 of about 1,289,803 (292)
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Endeavour, 1984
Abstract Since it was introduced into Europe from South America by the Jesuits at the beginning of the 17th century, quinine has been one of the most effective drugs for the treatment of malaria. During this century a number of synthetic antimalarial drugs have been introduced but while these have had considerable success their extensive and ...
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Abstract Since it was introduced into Europe from South America by the Jesuits at the beginning of the 17th century, quinine has been one of the most effective drugs for the treatment of malaria. During this century a number of synthetic antimalarial drugs have been introduced but while these have had considerable success their extensive and ...
openaire +2 more sources
Antiviral Research, 2006
Almost 30 years ago it was proposed that the selection for antiviral drug resistance should be used as an indicator of antiviral drug activity. In addition to discriminating between cellular toxicity and specific activity directed against a viral target, drug resistant mutants have been used to confirm the mechanism of action of antiviral drugs, to ...
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Almost 30 years ago it was proposed that the selection for antiviral drug resistance should be used as an indicator of antiviral drug activity. In addition to discriminating between cellular toxicity and specific activity directed against a viral target, drug resistant mutants have been used to confirm the mechanism of action of antiviral drugs, to ...
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Clinical Infectious Diseases, 2003
The increasing incidence of invasive fungal infections is the result of many factors, including an increasing number of patients with severe immunosuppression. Although new drugs have been introduced to combat this problem, the development of resistance to antifungal drugs has become increasingly apparent, especially in patients who require long-term ...
Juergen, Loeffler, David A, Stevens
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The increasing incidence of invasive fungal infections is the result of many factors, including an increasing number of patients with severe immunosuppression. Although new drugs have been introduced to combat this problem, the development of resistance to antifungal drugs has become increasingly apparent, especially in patients who require long-term ...
Juergen, Loeffler, David A, Stevens
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1955
Publisher Summary It is unfeasible and unnecessary to coerce the complex biological events contributing to the origin of resistance into a single theory. Experimental evidence suggests that a few models define most examples of resistance development, particularly if the models are so combined as to provide either genotypic or phenotypic alterations ...
V, BRYSON, W, SZYBALSKI
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Publisher Summary It is unfeasible and unnecessary to coerce the complex biological events contributing to the origin of resistance into a single theory. Experimental evidence suggests that a few models define most examples of resistance development, particularly if the models are so combined as to provide either genotypic or phenotypic alterations ...
V, BRYSON, W, SZYBALSKI
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Seminars in Respiratory and Critical Care Medicine, 2011
Influenza viruses are major human pathogens with a global distribution, accounting for more than 500,000 annual deaths worldwide and with considerable impact on the quality of life and productivity of the society. Due to the limited efficacy of vaccination, antiviral drugs constitute a complementary approach in the control and prevention of influenza ...
Andrés, Pizzorno +2 more
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Influenza viruses are major human pathogens with a global distribution, accounting for more than 500,000 annual deaths worldwide and with considerable impact on the quality of life and productivity of the society. Due to the limited efficacy of vaccination, antiviral drugs constitute a complementary approach in the control and prevention of influenza ...
Andrés, Pizzorno +2 more
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Disease-a-Month, 2006
Eastern Europe, Henan province in China, and certain parts of Russia. 1 The resistance to single drug was reported to range from 2 to 41% (median 9.9%) and to multiple drugs was 0 to 14.4% (prevalence 1.4%) in those who never received prior treatment.
Joel Anthony, Nations +2 more
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Eastern Europe, Henan province in China, and certain parts of Russia. 1 The resistance to single drug was reported to range from 2 to 41% (median 9.9%) and to multiple drugs was 0 to 14.4% (prevalence 1.4%) in those who never received prior treatment.
Joel Anthony, Nations +2 more
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Molecular Genetics, Microbiology and Virology (Russian)
Genetic control of different pathways of drug-resistance formation in bacteria is presented. Possible molecular mechanisms of “new” genes integration into the genomes by horizontal gene transfer are discussed. This review may be valuable for physicians, veterinarians and scientific researches engaged in bacterial evolution.
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Genetic control of different pathways of drug-resistance formation in bacteria is presented. Possible molecular mechanisms of “new” genes integration into the genomes by horizontal gene transfer are discussed. This review may be valuable for physicians, veterinarians and scientific researches engaged in bacterial evolution.
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Current Opinion in Pulmonary Medicine, 2000
There is increasing concern in many countries about the problem of drug-resistant tuberculosis, particularly so because no new classes of drugs have been developed for the treatment of tuberculosis since the 1960s. Although drug resistance is thought to be fairly common in some countries and rare in others, the global extent of this condition is not ...
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There is increasing concern in many countries about the problem of drug-resistant tuberculosis, particularly so because no new classes of drugs have been developed for the treatment of tuberculosis since the 1960s. Although drug resistance is thought to be fairly common in some countries and rare in others, the global extent of this condition is not ...
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Medicinal Research Reviews, 1999
Multiple drug resistance to antibacterial agents, antifungals, antivirals, antiprotozoals, and antitumor agents has risen spectacularly in the last decade or so and presently threatens eventually to put an end to successful chemotherapy in all of the above fields.
L A, Mitscher +3 more
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Multiple drug resistance to antibacterial agents, antifungals, antivirals, antiprotozoals, and antitumor agents has risen spectacularly in the last decade or so and presently threatens eventually to put an end to successful chemotherapy in all of the above fields.
L A, Mitscher +3 more
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