Results 81 to 90 of about 1,289,803 (292)

Zinc pyrithione impairs iron-sulfur cluster biogenesis in Mycobacterium tuberculosis

BMC Microbiology
Background Tuberculosis remains a major global health threat, especially with the increasing prevalence of drug-resistant Mycobacterium tuberculosis (Mtb). There is an urgent need to develop new antibiotics with novel mechanisms of action.
Lu Wang, Xuelin Wang, Lingling Xu, Bin Wang, Deqian Ji, Yangxue Ye, Yu Lu   +6 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Peer Review #3 of "Identification of potential glioma drug resistance target proteins based on ultra-performance liquid chromatography-mass spectrometry differential proteomics (v0.1)"

, 2023

openalex   +1 more source

MTBDRplus and MTBDRsl for simultaneous diagnosis of gastrointestinal tuberculosis and detection of first‐line and second‐line drug resistance [PDF]

, 2023
Kusum Sharma, Megha Sharma, Vishal Sharma, Megha Sharma, Uday Pratap Singh Parmar, Jayanta Samanta, Aman Sharma, Rakesh Kochhar, Saroj Kant Sinha   +8 more
openalex   +1 more source

Introduction: Drug Resistance [PDF]

Chemical Reviews, 2021
Nese Kurt Yilmaz, Celia A. Schiffer
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Machine learning reveals targets of Gnaphalium hypoleucum DC. flavonoids against rheumatoid arthritis through gut microbiota and anti-inflammation

Frontiers in Immunology
BackgroundRheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and gut microbiota dysbiosis. Gnaphalium hypoleucum DC.
Yu-Long Li, Zi-Yong Chu, Ding-Hui Xu, Ding-Hui Xu, Shu-Yun Wei, Ya-Si Nong, Xiao-Xi Luo, Yi-Jing Wang, Hong Zeng   +8 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

PlyNJ3: a three-domain endolysin with broad-spectrum anti-streptococcal activity and synergistic efficacy against multidrug-resistant Streptococcus suis

BMC Veterinary Research
Background The global spread of multidrug-resistant (MDR) bacteria prompts the exploration of innovative antimicrobial strategies. Phage lysins—peptidoglycan hydrolases known for species-specific activity and low resistance potential—offer promising ...
Jiaqi Zhao, Jingju Wang, Peizhao Han, Cai Yin, Shushu Gu, Hui Ji, Xiaoming Wang, Liping Wang, Jinhu Huang   +8 more
doaj   +1 more source