Results 221 to 230 of about 517,836 (269)

Inhaled Angiopoietin‐Like 4 Antisense Oligonucleotide Therapy for Lung Injury and Fibrosis

Advanced Science, EarlyView.
Inhaled antisense oligonucleotides targeting ANGPTL4 attenuate inflammation, preserve barrier integrity, and reduce fibrosis in both infectious and sterile lung injury models. Integrated transcriptomic analysis reveals a conserved ANGPTL4‐regulated gene network coordinating hypoxic, inflammatory, apoptotic, and stress‐response pathways.
Haiyang Fan, Yuanyang Tan, Junhang Zhang, Xiaoya Liu, Jing Qu, Damien Chua, Hong Sheng Cheng, Joseph Han Sol Kim, Yu Xuan Liu, Changfei Qin, Yingzi Liu, Dezhi Li, Jikang Qiu, Mengshi Chi, Mingmin Bi, Qiwei Zhang, Yun Li, Masoumeh Motamedi Joibari, Stefan K Nilsson, Nguan Soon Tan, Yunping Fan, Liang Li   +21 more
wiley   +1 more source

Antiviral drug discovery and development: challenges and future directions. [PDF]

Signal Transduct Target Ther
Du S, Hu X, Li P, Xu S, Kim M, Liu X, Zhan P.   +6 more
europepmc   +1 more source

Indole‐3‐Propionic Acid Improves Alveolar Development Impairment via Targeting VAMP8‐mediated SNAREs Complex Formation in Bronchopulmonary Dysplasia

Advanced Science, EarlyView.
This study aims to evaluate the impact of the tryptophan‐derived metabolite indole‐3‐propionic acid (IPA) on lung development and autophagic flux. IPA alleviates hyperoxia‐induced alveolar arrest by promoting autophagosome‐lysosome fusion via inhibition of VAMP8 phosphorylation, which is suggestive of a promising therapeutic target of BPD.
Beibei Wang, Xu Chen, Haowei Xu, Zhiqi Zeng, Keyu Lu, Yu Mao, Qianru Lv, Hui Shi, Song Liu, Xian Shen, Chunyu Yin, Yang Yang, Yan Guo, Xingyun Wang, Rui Cheng   +14 more
wiley   +1 more source

A physics-informed graph neural network to approximate docking-based binding affinity for DYRK2 in Alzheimer's drug repurposing. [PDF]

Sci Rep
Gider V, Budak C.
europepmc   +1 more source

Defining the chromatin-associated protein landscapes on <i>Trypanosoma brucei</i> repetitive elements using synthetic TALE proteins. [PDF]

Elife
Carloni R, Devlin T, Tong P, Spanos C, Auchynnikava T, Rappsilber J, Matthews KR, Allshire RC.   +7 more
europepmc   +1 more source

Multitarget docking and molecular enumeration reveal DdpMPyPEPhU as a potent modulator of cell cycle, glucocorticoid, and estrogen signalling in breast cancer. [PDF]

PLoS One
Ahmad S, Qazi S, Bano N, Uddin R, Gautam PK, Raza K.   +5 more
europepmc   +1 more source

Virtual Screening and MD Simulation-Driven Discovery of USP7 Inhibitors BML-284. [PDF]

ACS Omega
Liu T, Yan W, Hu X, Qu J, Liu J, Wang Q, Yin H, Li Z.   +7 more
europepmc   +1 more source

GraphDTA for predicting drug–target binding affinity

openaire   +1 more source

Exploring imidazo[1,2-a]pyridine hybrids in cancer therapy: ADMET profiling, molecular docking, MD simulations and DFT calculations. [PDF]

Sci Rep
Shah D, Nagani A, Shah M, Patel A.
europepmc   +1 more source