Results 251 to 260 of about 522,701 (266)

Hierarchical graph representation learning for the prediction of drug-target binding affinity

Information Sciences, 2022
exaly  

The role of ligand efficiency metrics in drug discovery

Nature Reviews Drug Discovery, 2014
Gyorgy M Keseru, Paul D Leeson, Charles H Reynolds   +2 more
exaly  

Drug–target residence time and its implications for lead optimization

Nature Reviews Drug Discovery, 2006
Robert A Copeland
exaly  

Thermodynamics and Kinetics of Drug-Target Binding by Molecular Simulation

Chemical Reviews, 2020
Sergio Decherchi, Andrea Cavalli
exaly  

Applying thermodynamic profiling in lead finding and optimization

Nature Reviews Drug Discovery, 2015
Gerhard Klebe
exaly  

Identifying drug-target binding affinity using spatial positions

Lakshya Jindal, Prerna Sharma, Tanmye Gorain, Rachit Agarwal, JaiShree Jain   +4 more
openaire   +1 more source

The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery

Nature Reviews Drug Discovery, 2010
Li Di
exaly  

DHAG-DTA: Dynamic Hierarchical Affinity Graph Model for Drug-Target Binding Affinity Prediction

IEEE Transactions on Computational Biology and Bioinformatics
Cheng Wang, Yang Liu, Shitao Song, Kun Cao, Xiaoyan Liu, Gaurav Sharma, Maozu Guo   +6 more
openaire   +1 more source

Angiogenesis Inhibitors: Current Strategies and Future Prospects

Ca-A Cancer Journal for Clinicians, 2010
Kristina M Cook, William D Figg
exaly  

Induced protein degradation: an emerging drug discovery paradigm

Nature Reviews Drug Discovery, 2016
Craig M Crews
exaly