Results 191 to 200 of about 11,649,511 (362)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Molecular dynamics insights into non-covalent functionalization of boron nitride nanotubes for doxorubicin delivery. [PDF]

Sci Rep
Ghavi Z, Torrik A, Rezaee M, Zarif M.
europepmc   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Multi-laboratory comparisons of manual patch clamp hERG data generated using standardized protocols and following ICH S7B Q&A 2.1 best practices. [PDF]

Sci Rep
Alvarez Baron C, Zhao J, Yu H, Ren M, Thiebaud N, Guo D, Vegesna G, Hsiao CH, DePalma R, Mistry S, Tariq I, Roni MSR, Ismaiel OA, Matta MK, Patel V, Mashaee M, Vicente J, Johannesen L, Sheng J, Hebeisen S, Kramer J, Bruening-Wright A, Nakano K, Matsukawa H, Pierson JB, Wu WW.   +25 more
europepmc   +1 more source

THE PORTABILITY OF DRUGS IN FIELD SERVICE. [PDF]

, 1881
Gillian Woodward, J.L Niven
openalex   +1 more source

Microglia limit brain tumor development by restricting tumor cell proliferation and inducing T‐cell immunity

Molecular Oncology, EarlyView.
Microglia (BV2) and IL‐4‐treated BMDMs promote astrocytoma clustering and inhibit tumor growth, not shown in other macrophage cells. In vivo, microglial co‐implantation enhances CD8+ T cell infiltration, elevates Granzyme B, lowers circulating MDSCs, and extends survival only in immune‐competent mice, but not in immune‐deficient mice.
Tzu‐Chieh Sun, Ching‐Fang Yu, Sheng‐Yan Wu, Wei‐Chung Cheng, Chi‐Shiun Chiang, Fang‐Hsin Chen   +5 more
wiley   +1 more source

Heterogeneous network drug-target interaction prediction model based on graph wavelet transform and multi-level contrastive learning. [PDF]

Sci Rep
Dai W, Wang Y, Yan S, Yu Q, Cheng X.
europepmc   +1 more source

TREATMENT OF MORPHIA HABITUÉS BY SUDDENLY DISCONTINUING THE DRUG. [PDF]

, 1884
S. A. K. Strahan
openalex   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Polydopamine-coated double emulsion capsules for on-demand drug release with reduced passive leakage. [PDF]

Sci Rep
Lee H, Nam G, Han D.
europepmc   +1 more source