Results 231 to 240 of about 8,662,910 (358)

Intelligent nanoparticles for advanced drug delivery in cancer treatment

, 2015
David S. Spencer, Amey S. Puranik, Nicholas A. Peppas   +2 more
openalex   +2 more sources

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

In silico drug sensitivity predicts subgroup-specific therapeutics in medulloblastoma patients. [PDF]

Sci Rep
Jermakowicz AM, Ruiz L, Chu J, Jangde N, Suter RK, Kadan-Lottick NS, Hanson D, Ayad NG.   +7 more
europepmc   +1 more source

Cloning, expression, purification, and structural modeling of the Chandipura virus matrix protein

FEBS Open Bio, EarlyView.
This research protocol offers a guide for the cloning, expression, and purification of the Chandipura virus matrix protein using E. coli. It also includes a step‐by‐step procedure for cloning, expressing, and conducting fluorescence imaging of GFP‐fused Chandipura virus matrix protein in mammalian cell lines.
Mariana Grieben
wiley   +1 more source

Contrastive learning-based multi-mechanism disentangled assessment for drug-drug interaction. [PDF]

BMC Bioinformatics
Zhang J, Zeng Y, Tang C, Zhong C, Wen H, Liu Y.   +5 more
europepmc   +1 more source

Autoencoder Based Feature Selection Method for Classification of Anticancer Drug Response [PDF]

, 2019
Xiaolu Xu, Hong Gu, Yang Wang, Jia Wang, Pan Qin   +4 more
openalex   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Single-cell sequencing and organoids: applications in organ development and disease. [PDF]

Mol Biomed
Li T, Yin J, Hao Y, Gao W, Li Q, Feng Q, Tao B, Hao M, Liu Y, Lin C, Wang D.   +10 more
europepmc   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

DrugMiner: comparative analysis of machine learning algorithms for prediction of potential druggable proteins

, 2016
Ali Akbar Jamali, Reza Ferdousi, Saeed Razzaghi, Jiuyong Li, Reza Safdari, Esmaeil Ebrahimie   +5 more
openalex   +2 more sources