Results 241 to 250 of about 12,292,416 (404)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A view on drug resistance in cancer

Nature, 2019
N. Vasan, J. Baselga, D. Hyman
semanticscholar   +1 more source

The ACCEPTance of automation: refining circulating tumor cells enumeration for improved metastatic colorectal cancer prognosis

Molecular Oncology, EarlyView.
This study highlights the potential of automated enumeration using the ACCEPT software to refine circulating tumor cell (CTC) detection in metastatic colorectal cancer (mCRC). The automated method demonstrates improved accuracy and reduced variability compared to the manual approach.
Michela De Meo, Marco Siringo, Alessandro Vici, Ann Zeuner, Orietta Gandini, Paola Gazzaniga, Chiara Nicolazzo   +6 more
wiley   +1 more source

SMPR: a structure-enhanced multimodal drug‒disease prediction model for drug repositioning and cold start. [PDF]

J Cheminform
Dong X, Miao R, Zhang S, Jia S, Zhang L, Liang Y, Zhang J, Zhu YZ.   +7 more
europepmc   +1 more source

Report of A Symposium on the Storage of Drugs and Medicines [PDF]

, 1949
T. E. Wallis, Janet Lloyd
openalex   +1 more source

Applications of machine learning in drug discovery and development

Nature reviews. Drug discovery, 2019
J. Vamathevan, Dominic Clark, P. Czodrowski, I. Dunham, Edgardo Ferran, George Lee, Bin Li, A. Madabhushi, Parantu K. Shah, M. Spitzer, Shanrong Zhao   +10 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Clinical pharmacist-led medication review in patients with sepsis and septic shock in the intensive care unit: a non-randomized controlled study. [PDF]

BMC Health Serv Res
Aksoy M, İlerler EE, Karakurt S, Sancar M.   +3 more
europepmc   +1 more source

The effect of lowered muscle temperature on the action of neuromuscular blocking drugs in man

, 1959
Thomas H. Cannard, Eleanor Zaimis
openalex   +2 more sources

Trends in GPCR drug discovery: new agents, targets and indications

Nature reviews. Drug discovery, 2017
A. Hauser, Misty M. Attwood, M. Rask-Andersen, H. Schiöth, David E. Gloriam   +4 more
semanticscholar   +1 more source