Results 301 to 310 of about 12,292,416 (404)

Phenotypic plasticity in a novel set of EGFR tyrosine kinase inhibitor‐adapted non‐small cell lung cancer cell lines

FEBS Open Bio, EarlyView.
Phenotypic plasticity in a newly established set of EGFR inhibitor‐adapted NSCLC cell lines during adaptation and in established cell lines. Here, we introduce novel sublines of the EGFR‐mutant non‐small cell lung cancer (NSCLC) cell lines HCC827 and HCC4006 adapted to the EGFR kinase inhibitors gefitinib (HCC827rGEFI2μm, HCC4006rGEFI1μm), erlotinib ...
Tharsagini V. Nanthaprakash, Campbell W. Gourlay, Ina Oehme, Michelle D. Garrett, Jindrich Cinatl Jr, Mark N. Wass, Martin Michaelis   +6 more
wiley   +1 more source

Use of Biomarkers in Drug Development for Regulatory Purposes. [PDF]

Clin Transl Sci
Schuck RN, Sekar V.
europepmc   +1 more source

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source

Leveraging platinum-protein interactions to overcome chemoresistance. [PDF]

Nat Commun
Wang F, Braverman J, Eng G, Leylek O, Petrone NL, Honeycutt DS, Imada S, Pallares B, Zhang D, Mrosla JM, Huang CS, Griadunova AA, McCarthy WK, Goldberg JM, Hemann MT, Lippard SJ, Yilmaz ÖH.   +16 more
europepmc   +1 more source

Phantastica: Narcotic and Stimulating Drugs, Their Use and Abuse

, 1935
Elsie Murray, Louis Lewin, Philip W. Wirth   +2 more
openalex   +1 more source

Polydatin ameliorates ovalbumin‐induced asthma in a rat model through NCOA4‐mediated ferroautophagy and ferroptosis pathway

FEBS Open Bio, EarlyView.
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li, Yuwei Tang, Wenkang Liu, Fang Fang, Jiepeng Wang, Chaoyi Fang   +5 more
wiley   +1 more source

DIRseq as a method for predicting drug-interacting residues of intrinsically disordered proteins from sequences. [PDF]

Elife
MacAinsh M, Qin S, Zhou HX.
europepmc   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

From Lab to Clinic: Success Stories of Repurposed Drugs in Treating Major Diseases. [PDF]

Adv Pharmacol Pharm Sci
Hussain MS, Mir PA, Kumar N, Mohi-Ud-Din R, Wali AF, Mir RH, Talath S, Sridhar SB, Shareef J, Goud M, Rangraze I, El-Tanani M, Ooi J.   +12 more
europepmc   +1 more source

Importance of drug-drug interactions in drug safety

, 2004
Rätz Bravo, Alexandra Elisabeth
openaire   +3 more sources