Results 311 to 320 of about 12,292,416 (404)

Menthol‐like cooling compounds, including (R)‐(‐)‐carvone, inhibit the human bitter taste receptors for saccharin and acesulfame K

FEBS Open Bio, EarlyView.
We report that some menthol‐like cooling compounds, including (R)‐(‐)‐carvone, act as inhibitors of TAS2R31 and TAS2R43, which are taste receptors responsible for the intrinsic bitter aftertastes of saccharin and acesulfame K. However, there was little correlation between the intensity of the cooling sensation and the potency of bitterness inhibition ...
Miyuu Saito, Takumi Misaka
wiley   +1 more source

Composite Hydrogels with Embedded Electrospun Fibers as Drug Delivery Systems. [PDF]

Gels
Fuioaga PC, Rata DM, Riaz T, Rivero G, Abraham GA, Atanase LI.   +5 more
europepmc   +1 more source

Cis‐unsaturated sphingolipids support growth of sphingoid base‐deficient yeast but impair plasma membrane integrity

FEBS Open Bio, EarlyView.
Sphingoid base structures, the sphingolipid backbones, vary among species. We established yeast cells in which the native sphingoid base was replaced with plant‐type bases containing cis or trans double bonds. This is, to our knowledge, the first eukaryotic model mostly composed of sphingolipids containing cis‐unsaturated sphingoid base, providing a ...
Takashi Higuchi, Saki Sugihara, Yohei Ishibashi, Kono Yushi, Hazuki Yamauchi, Motohiro Tani   +5 more
wiley   +1 more source

Fabrication and characterization of polysaccharide-based microspheres for ciprofloxacin delivery with controlled release and antimicrobial activity. [PDF]

RSC Adv
Ameer QUA, Ghumman SA, Hameed H, Noreen S, Noureen S, Kausar R, Irfan A, Kotwica-Mojzych K, Batool F, Glowacka M, Rana M, Mojzych M, Bin Jardan YA.   +12 more
europepmc   +1 more source

Statins induce monocytic differentiation in acute myeloid leukemia cells through the KLF4/DPYSL2A axis

FEBS Open Bio, EarlyView.
Statins, identified via the Comparative Toxicogenomics Database, promote monocytic differentiation and apoptosis in non‐APL AML cells by upregulating DPYSL2A through a KLF4‐dependent pathway. Mevalonate supplementation reversed these effects, indicating involvement of the mevalonate pathway.
Mina Noura, Kota Shoji, Michidai Nobe, Moe Ishikawa, Miu Tanaka, Akiko Okayama, Souichi Adachi, Hidemasa Matsuo   +7 more
wiley   +1 more source

High-Throughput Computing to Detect Harmful Drug-Drug Interactions in Older Adults: Protocol for a Population-Based Cohort Study.

JMIR Res Protoc
Rostamzadeh N, Sharma R, Abdullah SS, McArthur E, Chalabianloo N, Sontrop JM, Weir MA, Sedig K, Garg AX, Muanda FT.   +9 more
europepmc   +1 more source

Checklist-Based Identification of Adverse Drug Reactions in Emergency Department Patients. [PDF]

Medicines (Basel)
Hellinger BJ, Bertsche T, Remane Y, Gries A.   +3 more
europepmc   +1 more source

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach

FEBS Open Bio, EarlyView.
This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang   +10 more
wiley   +1 more source

Long-Term Safety Evaluations in the Presence of Switching: Evaluation of Two Approaches. [PDF]

Pharm Stat
Schmeller S, Izem R, Romero PL, Jehl V.
europepmc   +1 more source