Results 361 to 370 of about 5,685,542 (420)
Some of the next articles are maybe not open access.
Maximum entropy and drug absorption
Journal of Pharmacokinetics and Biopharmaceutics, 1991The application of maximum entropy to the calculation of drug absorption rates was introduced in an earlier paper. Here it is developed further, and the whole procedure is presented as a problem in scientific inference to be solved using Bayes' theorem.
M. K. Charter, S. F. Gull
openaire +3 more sources
Effects of Food on Drug Absorption
Annual Review of Nutrition, 1989This chapter provides an update on drug-food interactions reported in the literature during the past five years. The number of studies examining this phenomenon has increased dramatically, and many of the results of these studies have been unpredictable and spectacular.
openaire +4 more sources
Drug Transporters of Intestinal Absorption
Chinese Journal of Natural Medicines, 2008口服药物在肠道中的吸收是决定药物生物利用度的重要因素.肠道中有许多介导药物转运的蛋白,在药物的吸收、分布和相互作用方面起关键的作用.本文通过介绍一些常见的肠道膜转运蛋白及其转运机制,提出利用转运蛋白的特性和转运蛋白底物之间的相互作用,提高药物的生物利用度.并对中药成分中的一些转运蛋白底物及中药一西药之间的相互作用进行了阐述.
Zhu Xiao-xin, Dong Yu, Yang Qing
openaire +2 more sources
Rate- and Extent-Limiting Factors of Oral Drug Absorption: Theory and Applications.
Journal of Pharmacy and Science, 2015The oral absorption of drugs has been represented by various concepts such as the absorption potential, the maximum absorbable dose, the biopharmaceutics classification system, and in vitro-in vivo correlation.
K. Sugano, K. Terada
semanticscholar +1 more source
Molecular Pharmaceutics, 2015
In this study, the data of 113 human bioequivalence (BE) studies of immediate release (IR) formulations of 74 active pharmaceutical ingredients (APIs) conducted at Sawai Pharmaceutical Co., Ltd., was analyzed to understand the factors affecting intra ...
Masahisa Sugihara +5 more
semanticscholar +1 more source
In this study, the data of 113 human bioequivalence (BE) studies of immediate release (IR) formulations of 74 active pharmaceutical ingredients (APIs) conducted at Sawai Pharmaceutical Co., Ltd., was analyzed to understand the factors affecting intra ...
Masahisa Sugihara +5 more
semanticscholar +1 more source
Methylxanthines and intestinal drug absorption
Naunyn-Schmiedeberg's Archives of Pharmacology, 19761. Jejunal loops of anaesthetized rats were filled with buffered isotonic solutions of tritiated water (HTO), urea, antipyrine and salicylic acid at pH 6-8. The venous outflow and the appearence rate of the substances in the intestinal venous blood were determined.
Eckhard Beubler, Fred Lembeck
openaire +3 more sources
Drug delivery and in vivo absorption
2022It is probably not well known that 4000 years B.C. Sumerians were able to prepare many medicaments and illness was considered a sort of divine punishment while healing was the consequent purification, a viewpoint that have heavily affected the western world up to the modern age.
Michela Abrami +7 more
openaire +4 more sources
Prediction of drug absorption using multivariate statistics.
Journal of Medicinal Chemistry, 2000Literature data on compounds both well- and poorly-absorbed in humans were used to build a statistical pattern recognition model of passive intestinal absorption. Robust outlier detection was utilized to analyze the well-absorbed compounds, some of which
W. Egan, K. Merz, J. Baldwin
semanticscholar +1 more source
2016
The understanding and the prediction of oral drug absorption are of great interest for pharmaceutical drug development. Obviously, the establishment of a comprehensive framework in which the physicochemical properties of drug candidates are quantitatively related to the extent of oral drug absorption will accelerate the screening of candidates in the ...
Macheras, P., Iliadis, A.
openaire +2 more sources
The understanding and the prediction of oral drug absorption are of great interest for pharmaceutical drug development. Obviously, the establishment of a comprehensive framework in which the physicochemical properties of drug candidates are quantitatively related to the extent of oral drug absorption will accelerate the screening of candidates in the ...
Macheras, P., Iliadis, A.
openaire +2 more sources
Absorption of Peptide and Peptidomimetic Drugs
Annual Review of Pharmacology and Toxicology, 1994Peptide drug delivery has been of considerable interest for the past 10 to 15 years, due in part to the availability of therapeutic proteins on a commercial scale. The advent of biotechnology and advances in peptide synthesis have made the synthesis of small peptides almost routine.
Gordon L. Amidon, H J Lee
openaire +3 more sources