Results 91 to 100 of about 577,363 (331)

Parenteral systems for statin delivery: a review

Lipids in Health and Disease, 2019
The oral route of drug administration is the most common and convenient route for dosing statin drugs, and, in fact, most medications, because of ease of drug delivery, patient compliance, and cost-effectiveness.
Shahla Korani, Samira Bahrami, Mitra Korani, Maciej Banach, Thomas P. Johnston, Amirhossein Sahebkar   +5 more
doaj   +1 more source

Endocytic Programming via Porous Silicon Nanoparticles Enhances TLR4 Nanoagonist Potency for Macrophage‐Mediated Immunotherapy

Advanced Functional Materials, EarlyView.
Porous silicon nanoparticles (PSiNPs) reprogram macrophage endocytosis of manganese@albumin‐based TLR4 nanoagonists, driving TRIF‐biased TLR4 signaling, eliciting robust proinflammatory responses, and potentiating macrophage‐mediated immunotherapeutic effects against NSCLC.
Xiaomei Zhang, Huiying Li, Shuodan Huang, Linxuan Zhang, Yan Gao, Ruoran Wang, Xiaoyu Wang, Hélder A. Santos, Zhenyu Yin, Bing Xia   +9 more
wiley   +1 more source

Morfina intratecale a basse dosi versus dosi di conversione nel dolore da cancro - Lower intrathecal morphine soses versus conversione doses in cancer pain

Pathos, 2011
Advanced studies in cancer related pain have demonstrated that intrathecal administration of opioids has been much more effective than otherdrug-administrating routes.1-5 The most frequently used drug has been morphine which is the first opioid approved ...
Francesco Amato, Roberto Siciliano, Monica Loizzo   +2 more
doaj  

Cholesterol in mRNA‐Lipid Nanoparticles can be Replaced with the Synthetic Mycobacterial Monomycoloyl Glycerol Analogue MMG‐1

Advanced Functional Materials, EarlyView.
This study demonstrates that cholesterol in messenger RNA‐lipid nanoparticles (mRNA‐LNPs) can be completely replaced with an immunopotentiating lipid, i.e., a synthetic analogue of the C‐type lectin receptor agonist monomycoloyl glycerol (MMG‐1), without compromising physicochemical properties, in vivo transfection efficiency, and immunogenicity of the
Abhijeet G. Lokras, Saahil S. Baghel, Rune F. Jensen, Aneesh Thakur, Henrik Franzyk, Oskar Thofte, Marco Herrera‐Barrera, Madeleine Landry, Melike Ongun, Ahmad Tami, Marlene P. Thanthrige, Eva Callens, Corinne Beinat, Thomas Rades, Søren R. Paludan, Kristian Riesbeck, Ida Rosenkrands, Dennis Christensen, Gabriel K. Pedersen, Camilla Foged   +19 more
wiley   +1 more source

Adverse events in different administration routes of amiodarone: a pharmacovigilance study based on the FDA adverse event reporting system

Frontiers in Pharmacology
BackgroundArrhythmias are prevalent cardiac disorders with significant impacts on patient quality of life and mortality. Amiodarone, a class III antiarrhythmic agent, is widely used to manage both atrial and ventricular arrhythmias due to its efficacy in
Jingrong Yang, Mengfan You, Jingxin Wang, Rongfei Sun, Lili Han, Xiaonan Liu, Kaibin Niu, Kaidi Xing, Juanping Sun, Wenge Su, Yifei Wang   +10 more
doaj   +1 more source

Chemo‐Mechanical Coupling in Hydrogels: Dynamics in the Diffusion‐Limited Regime

Advanced Functional Materials, EarlyView.
A time‐dependent continuum model is developed to capture the transient swelling dynamics of chemo‐mechanical hydrogels. By coupling chemical reactions, solvent transport, and polymer deformation, volume phase transitions, reaction kinetics, and transient mechanical instabilities are analyzed.
Yao Xiong, Aaveg Aggarwal, Monica Olvera de la Cruz   +2 more
wiley   +1 more source

Patients' Perceptions of Route of Nonsteroidal Anti‐inflammatory Drug Administration and Its Effect on Analgesia [PDF]

, 2000
Nicholas A. Schwartz, Michael A. Turturro, David J. Istvan, Gregory Luke Larkin   +3 more
openalex   +1 more source

Probing Early Particle‐Cell Membrane Interactions via Single‐Cell and Single‐Particle Interaction Analysis

Advanced Functional Materials, EarlyView.
The pre‐internalization phase of endocytosis remains poorly characterized at single‐cell levels. Single‐cell pre‐internalization mechanics are investigated using advanced robotic techniques. Cancer cells exhibit biphasic adhesion – rapid initial binding followed by reinforcement – while fibroblasts show gradual engagement.
Houari Bettahar, Christos Tapeinos, Oğulcan Işıtman, Carmine D'Amico, Alexandra Correia, Hélder A. Santos, Quan Zhou   +6 more
wiley   +1 more source

Advances in Allergen Immunotherapy and Safety

Vaccines
Allergen immunotherapy (AIT) modifies immune responses to treat allergies. AIT treatment is a 3-month to 3-year long-term strategy, and its potential candidates are allergic rhinitis and asthma, food allergy, and insect venom allergy.
Samia T. Al-Shouli
doaj   +1 more source

Absorption of phenolsulfonphthalein as a model across the mesenteric surface in rats to determine the drug absorption route after intraperitoneal administration [PDF]

, 2004
Koyo Nishida, Seiichi Nose, Akiko Kuma, Takahiro Mukai, Mikiro Nakashima, Hitoshi Sasaki, Junzo Nakamura   +6 more
openalex   +1 more source