Results 281 to 290 of about 577,363 (331)
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The Effect of Route of Administration on the Cimetidine‐Theophylline Drug Interaction
The Journal of Clinical Pharmacology, 1989The effect of route of cimetidine administration on cimetidine‐mediated inhibition of theophylline oxidation was examined in healthy individuals. Based on the evidence that cimetidine‐mediated inhibition of drug oxidation is competitive and, therefore, dependent on cimetidine concentration in the liver, oral cimetidine was tested to determine whether ...
Kermit V Speeg +2 more
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Drug delivery systems and routes of administration of peptide and protein drugs
European Journal of Drug Metabolism and Pharmacokinetics, 1990The unique requirements of peptides and proteins in designing delivery systems, and the unprecedented recent growth in the field, has driven a great deal of research into novel means of drug delivery. The search for approaches that provide formulations that are stable, bioavailable, readily manufacturable, and acceptable to the patient, has led to ...
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Estimating Dose Equivalence for New Routes of Drug Administration
Journal of Biopharmaceutical Statistics, 2004For patient's convenience, dose administration of insulin via oral inhalation is often considered as an alternative to subcutaneous administration. An important statistical problem is to estimate dose equivalence, which is the amount of drug needed to be delivered by inhalation to generate an equivalent pharmacokinetic (PK) response produced by a ...
G Weerakkody +3 more
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Cancer Chemotherapy: Alternative Routes of Drug Administration. A Review
Cancer Drug Delivery, 1985This review covers recent developments in regional cancer chemotherapy, including the pharmacological background, technical progress, and clinical experience. Intrathecal chemotherapy is an approach that has acquired an established place, although its ultimate potentials are not known yet. The therapeutic value of hepatic intraarterial drug infusion is
H.J. Keizer, H.M. Pinedo
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European journal of drug metabolism and pharmacokinetics, 2017
Pengyue Li +9 more
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Pengyue Li +9 more
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[Controlled-release drugs: administration routes and formulations].
Annales pharmaceutiques francaises, 2001The notion of controlled release has been known since the 1930s, but was not significantly developed until the 1970s. At that time, Alza introduced the concept of a "therapeutic system" and proposed new pharmaceutic formulations. Over time, the idea became one of controlled drug delivery and today concerns not only one rate of release but also the site
NICOLI, Sara, COLOMBO, Paolo
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Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies
Ca-A Cancer Journal for Clinicians, 2022Paolo Tarantino +2 more
exaly
Effect of Route of Administration and Distribution on Drug Action
2009The ultimate goal of drug therapy is to deliver an active pharmaceutical agent to the site(s)within the body where it can exert its desired action. Once a drug is absorbed or deliveredto the bloodstream, multiple steps are involved in the process of subsequently deliveringthe drug to its active site, and the steps involved are commonly referred to as ...
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The effects of treatment failure generalize across different routes of drug administration
Science Translational Medicine, 2017M. Zunhammer +5 more
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Administration Routes for Nano Drugs and Characterization of Nano Drug Loading
Characterization and Biology of Nanomaterials for Drug Delivery, 2019V. Nikolić +4 more
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