Results 141 to 150 of about 144,045 (218)

Patient‐Derived 3D‐Bioprinted Intrahepatic Cholangiocarcinoma Models Recapitulate Tumor Autologous Traits and Predict Personalized Adjuvant Therapy

Advanced Science, EarlyView.
Leveraging 3D bioprinting, this study establishes patient‐derived in vitro models of intrahepatic cholangiocarcinoma. These models faithfully recapitulate the histopathology, molecular profiles, and genomic characteristics of the original patient tumors.
Yuce Lu, Liwei Du, Minghao Sun, Kai Zhang, Mingchang Pang, Shangze Jiang, Jiaxun Dong, Xiyue Liu, Bao Jin, Fu Xu, Hang Sun, Jiangang Zhang, Huiyu Yang, Xiaobo Yang, Xin Lu, Yiyao Xu, Haitao Zhao, Shunda Du, Xinting Sang, Yongchang Zheng, Lei Zhang, Xueshuai Wan, Huayu Yang, Yilei Mao   +23 more
wiley   +1 more source

Randomized Phase 2 Trial of an Extended and Flexible Dosing Schedule of ¹⁷⁷Lu-PSMA Molecular Radiotherapy in Patients with Metastatic Castration-Resistant Prostate Cancer (FLEX-MRT): Study Protocol. [PDF]

J Nucl Med
Holzgreve A, Delker A, Ells Z, Brosch-Lenz J, Unterrainer LM, Nikitas J, Zhu S, Contreras MM, Alam H, Nabong RM, Lira S, Vasilyev A, Chen L, Grogan T, Elashoff D, Meyer CA, Dahlbom M, Czernin J, Calais J.   +18 more
europepmc   +1 more source

A Prussian Blue Nanozyme‐Adjuvanted Vaccine Presenting Phosphocholine Antigens for Induction of Immunotolerance in Inflammatory Bowel Disease

Advanced Science, EarlyView.
This study developed a novel nano‐vaccine (Ferritin‐PC@PBNZs) comprising a ferritin‐based scaffold for the multivalent display of phosphorylcholine (PC) antigens, integrated with Prussian blue nanozymes (PBNZs) as a potent adjuvant. By leveraging the ferritin carrier for high‐density and ordered antigen display, the nano‐vaccine significantly augments ...
Jingyi Sheng, Yubo Huang, Xinyue Li, Yin Liu, Yuehuang Wu, Yuxin Zhang, Ning Gu   +6 more
wiley   +1 more source

Intramuscular Cyanocobalamin Treatment in Patients with Corpus Atrophic Gastritis and Vitamin B₁₂ Deficiency: Efficacy and Predictors of Increased Requirement-A Monocentric Longitudinal Real-Life Cohort Study. [PDF]

Nutrients
Schiavone FP, Pivetta G, Scalamonti S, Pompili M, Magnante M, Esposito G, Annibale B, Lahner E.   +7 more
europepmc   +1 more source

Ubiquitination‐Driven Reprogramming of Proteostasis in Metastasis

Advanced Science, EarlyView.
The DCAF12–TRiC/CCT axis is a key regulator of metastasis in cancer. By reprogramming proteostasis to ensure efficient protein folding, it drives progression through a dual mechanism: enhancing cancer cell motility and invasiveness while concurrently activating pro‐growth and survival pathways.
Dongping Wei, Jiayan Chen, Yaping Xu
wiley   +1 more source

Nicotine enhances the ability of cues to control behavior and evoke dopamine release in the dorsolateral striatum. [PDF]

J Pharmacol Exp Ther
Leonard MZ, Elam HB, Yoon HJ, Lago SH, Altemus ME, Roberts S, Chevée M, Calipari ES.   +7 more
europepmc   +1 more source

CXC Chemokine‐Driven Vascular Reprogramming: Modulating Tumor Vasculature to Boost Therapeutic Response

Advanced Science, EarlyView.
Tumor vascular remodeling is discussed from a chemokine‐centered perspective. This review summarizes the bidirectional, temporal, and tissue‐specific roles of CXC chemokines in regulating vascular function and immune accessibility. A functional vascular normalization score is introduced as a conceptual framework to integrate dynamic vascular and immune
Hongdan Chen, Yinde Huang, Juntong Wu, Ziying Yi, Yao Li, Zeyu Yang, Fan Zhang, Chong Li   +7 more
wiley   +1 more source

Procedural separation of appetitive and consummatory behaviors in operant ethanol self-administration: A review and open-source analytical framework. [PDF]

Alcohol Clin Exp Res (Hoboken)
Colarusso OA, Weiner JL.
europepmc   +1 more source

Wearable Thermoelectric Generators for In Vivo Modulation of Insulin Release

Advanced Energy Materials, EarlyView.
This work presents a wearable, self‐powered thermoelectric system (IGNITE) that sustainably harvests body heat to electrically stimulate engineered human cells for insulin release. Operating autonomously without batteries, IGNITE achieves glycemic control in diabetic mice, demonstrating a significant advance in bioelectronic medicine and setting the ...
Debasis Maity, Jinbo Huang, Martin Fussenegger   +2 more
wiley   +1 more source

Treatment of Disturbed Sleep in Progressive Supranuclear Palsy: a randomized, remote, double-blinded, 6-week cross-over design study protocol comparing zolpidem, suvorexant, and placebo. [PDF]

Trials
Li E, Song F, Coppola Q, Yack L, Le M, Javed S, Pandher N, Prufer I, Mayzel O, Heuer HH, Koestler M, Miller BL, Boxer AL, Vandevrede L, Grinberg LT, Walsh CM, Neylan TC.   +16 more
europepmc   +1 more source